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Acne Treatment - Europe PMC

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Last Updated: 10 December 2022

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Red Light-Mediated Photoredox Catalysis Triggers Nitric Oxide Release for Treatment of Cutibacterium Acne Induced Intervertebral Disc Degeneration.

Intervertebral disc degeneration has been identified as a widespread and disabling disorder that is one of the key causes of low back pain and disability. Notably, the local delivery of NO does not only effectively remove C. acnes pathogens but also reduces inflammation and osteoclast differentiation in the intervertebral disc tissues, with antibacterial, anti-inflammatory, and antiosteoclastogenesis properties.

Source link: https://europepmc.org/article/MED/36469724


Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review.

During pregnancy and lactation, Acne vulgaris is a common problem for women. During the course of pregnancy, hormonal and physiologic changes have both contributed to acne formation. Several common acne treatments that are commonly used in the general population are contraindicated during pregnancy or lactation. We review existing studies on the safety and effectiveness of acne creams during pregnancy and breastfeeding in this narrative review. Acne control in pregnancy and lactation should take a stepwise approach based on severity in order to minimize risk.

Source link: https://europepmc.org/article/MED/36447117


Role of topical spironolactone in the treatment of acne: A systematic review of clinical trials-Does this therapy open a path towards favorable outcomes?

Acne vulgaris is the eighth most common disease worldwide, and it appears on inflammatory and noninflammatory skin lesions as well as other dermal abnormalities. Oral spironolactone is used for treating acne vulgaris due to its antiandrogenic activity and sebogenesis inhibition. Despite the fact that spironolactone in topical form has similar safety to its oral form, there are still fewer adverse events associated with its use, according to new research. In each study, the Cochrane risk of bias assessment system was used to determine the likelihood of bias. Patients treated with topical spironolactone showed a significant decrease in the number of papules, closed comedones, and lesions. Topical spironolactone cream produces improved results than other first-line acne treatments and has fewer side effects. However, further large-scale clinical trials are needed before spironolactone can be used as the preferred treatment in acne management.

Source link: https://europepmc.org/article/MED/36412248


Carbon Peeling Laser Treatment to Improve Skin Texture, Pores and Acne Lesions: A Retrospective Study.

Skin texture improvement has been praised, with pores reduction and acne lesion treatment, according to a carbon peel laser treatment. Despite the fact that this study is limited due to the small number of patients and its retrospective nature, this is the first study to show that carbon peel laser, administered with a standardized technique, is an effective and safe treatment for patients with acne lesions, showing pores and wrinkles, and can also improve the overall skin appearance.

Source link: https://europepmc.org/article/MED/36422207


The efficacy of an oral probiotic associated with a fixed combination of benzoyl peroxide and adapalene in the treatment of acne: A randomized, double-blind, placebo-controlled clinical trial.

Objective: A clinical study was conducted to determine the effectiveness of a drug regimen with an oral probiotic supplemented with a specific mixture of 0. 1% adapalene and 2. 5% benzoyl peroxide, relative to an oral placebo with the same topical therapy in patients with mild to moderate acne. Patients were treated with 2. 9 percent benzoyl peroxide and 0. 1% adapalene, respectively with a probiotic, or 2. 5% benzoyl peroxide and 0. 1 percent adapalene compared to placebo in the first phase. Result:: The test treatment arm receiving the test intervention was superior to the comparator group at all study time points, with a significant difference between the percentage of participants with IGA 0 or 1 u2013. Conclusion: Probiotic therapy for acne control should be considered an adjuvant therapy for acne control, considering the scientific evidence on efficacy and safety.

Source link: https://europepmc.org/article/PPR/PPR571375


A Systematic Review and Meta-analysis of Randomized Clinical Trials of Fire Needle Combined with ALA-PDT for the Treatment of Moderate-to- Severe Acne.

Background Moderate-to-severe acne affects people's wellbeing and quality of life. However, some patients do not tolerate pills as first-line therapeutic products, isotretinoin, and antibiotics were used to treat moderate-to-severe acne. Now, more scientific trials are being published on the treatment of moderate-to-severe acne treated by a combination of fire needle and ALA-PDT, providing us with a new approach to treating moderate-to-severe acne. This report reviewed the effectiveness and safety of moderate to severe acne treatment with fire needles and ALA-PDT in order to establish a foundation for clinical research. Methods By July 2022, search PubMed, the Chinese Biomedical Literature Database, the Cochrane Library, the Chinese Scientific Journal Database, the China National Knowledge Infrastructure, the Web of Science Datebase, Embase Datebase, and the WanFang Database; search PubMed, the Chinese Biomedical Literature Database, and the Beijing National Knowledge Infrastructure. The search PubMed, Embase Datebase, Visualization Database, and the WanFang Database. To treat moderate-to-severe acne, To gather RCTs of fire needle implantation with ALA-PDT. In terms of clinical safety, combination therapy outperformed monotherapy in terms of clinical safety. In terms of clinical safety, the combination therapy outperformed ALA-PDT alone, according to a new subgroup review. In addition, combination therapy outperformed fire needle alone in terms of clinical safety, efficacy determining clinical effectiveness. Studies have also shown that combination therapy has a higher chance of lowering the GAGS score. Conclusions Fire needle needle's effectiveness in the treatment of moderate-to-severe acne is superior to that of ALA-PDT or fire needle alone.

Source link: https://europepmc.org/article/MED/36384211

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions