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Acne scars are one of the most common skin disorders and can influence people's quality of life, so it has boosted the hunt for medications that can reduce or solve this imperfection. This paper was designed to describe a clinical case of a post acne scar treatment by the microneedle associated with PRP and iPRF, which was activated with oZu00f4nio.
Source link: https://doi.org/10.51249/hs.v2i05.991
Abstract Background Atrophic post-acne scarring causes a troubling cosmetic issue for both patients and dermatologists. The aim was to determine whether its combination with topical platelet-rich plasma was superior to its combination with topical Botulinum Toxin-A. Methods 30 subjects with varying amounts and grades of atrophic post-acne scars completed the research. While the right side of the face was treated with microneedling and platelet-rich plasma, while the left side was treated with microneedling and Botox, the left side was treated with microneedling and platelet-rich plasma, while the left side was treated with microneedling and botox. Regarding the change in the qualitative scarring grading framework before and after treatment, there was a substantial rise on both directions with higher growth on the right side over the left side but not in a non-statistically significant manner. Conclusions Both groups include safe options for treating acne scars with similar efficacy.
Source link: https://doi.org/10.1007/s00403-022-02446-9
Acne fulminans is a rare and inflammatory chronic form of acne most common in adolescent males. While the triggering agent for this condition has been speculated to be an explosive hypersensitivity reaction to Propionobacterium acnes, increased androgens, namely testosterone, has also been shown to play a role in this disease process. AF is primarily a medical diagnosis. This case report shows a refractory case of AF with dramatic clinical improvement after six weeks of topical therapy with subcutaneous adalimumab in combination with oral doxycycline. This case provides evidence demonstrating Adalimumab's involvement in the treatment of AF in comparison to other inflammatory disorders that are currently FDA-approved for treatment with this tumor-necrosis factor alpha inhibitor.
Source link: https://doi.org/10.51894/001c.7003
To produce the nanoemulgel, optimized nanoemulsion was suspended in 1. 0% w/v of Carbopol 940 gel, and for this, pH, viscosity, and spreadability were determined, and texture analysis was performed. Ex vivo skin permeation experiments were done with Franz diffusion cell using rat skin as the permeation membrane, and the nanoemulgel showed sustained-release results, to determine the extent of drug penetration between nanoemulsion and nanoemulgel. It can be concluded that the naoemulgel containing minocycline is expected to treat acne rosacea more efficiently.
Source link: https://doi.org/10.3390/pharmaceutics14112322
Cosmetic procedures can have a positive effect on skin condition by clearing up skin eruptions, thus improving affected individuals's well being. Hydrogen purification is a treatment that uses alkaline water produced by a device that eliminates sebum from the epidermis' surface. On the other hand, cosmetic acids have been used for many years to treat acne vulgaris patients and produce dramatic results in terms of skin condition. To determine acne severity, the Global Acne Grading System was used. Patients' skin eruptions were minimized and sebum on the epidermis' surface were also reduced, and skin hydration was also improved. However, the results in group B were higher than in group A. The study found that the synergy of the therapies had much better results than those obtained by finishing the hydrogen purification process alone.
Source link: https://doi.org/10.3390/jcm11216269
The aim of the research was to compare the effects of using only pyruvic acid and the synergy of microdermabrasion and chemical exfoliation. The study included 14 women with acne in total. According to GAGS, all patients had moderate acne before the treatments, and after the procedures, it diminished to mild acne. In all of the examined areas of the face, sebum secretion decreased in statistically significant reduction in the stratum corneum's hydration, on the right side of the face. In the case of increased hydration and reduction of sebum secretion, using only pyruvic acid treated, the use of microdermabrasion in conjunction with pyruvic acid resulted in improved outcomes.
Source link: https://doi.org/10.3390/jcm11206079
METHODS We conducted a retrospective, observational cohort study using electronic records from Health Data Compass at the University of Colorado Anschutz Medical Campus and its affiliates, with results in the form of the Observational Health Data Sciences and Informatics Partnership common data set. 988 men who were eligible for isotretinoin therapy in this population received a course of isotretinoin, compared to only 10. 4% eligible women. IN this controlled population, minocycline was the most commonly used antibiotic for acne treatment in this research group. Male patients were also 1. 67 times more likely to have obtained an antibiotic prescription and was over twice as likely to have received an isotretinoin prescription than female patients.
Source link: https://doi.org/10.2196/preprints.42883
In acne vulgaris patients under ITT therapy, the present study seeks to investigate the correlation between variations in serum lipid concentration, a side effect of isotretinoin, psychiatric signs, and suicidal expectation in acne vulgaris patients under ITT therapy. Patients were analyzed with the socio-demographic and clinical data collection system, Beck depression inventory, Beck anxiety questionnaire, Beck suicidal ideation scale, and Beck's suicide risk scales at the start and in the third month of therapy. Thus, it was found that there was no negative relationship between BSS and TC parameters, a marginal negative correlation between BSS and TG, and a weak negative correlation between BSS and LDL. The present study found that serum lipid levels could be correlated with psychiatric side effects in patients under ITT therapy.
Source link: https://doi.org/10.21203/rs.3.rs-1857768/v1
Abstract; Short-term exposures of immortalized sebocytes with isotretinoin have contradicting findings, suggesting that transcription is still a matter of contention. For six weeks, twenty-five patients with acne vulgaris were treated with isotretinoin. Biopsies from back skin were obtained before and after isotretinoin treatment for determining p53 expression by immunohistochemical staining, quantification of p53 protein content by enzyme-linked immunosorbent assay, and TP53 gene expression by quantitative reverse transcription real time PCR. Treatment and untreated controls showed significant elevations in the nuclear expression of p53 in treated patients' sebaceous glands, much higher than pre-treatment or p53 levels. Increased p53-FoxO1 signalling as a result of systemic isotretinoin treatment increases p53-FoxO1 gene expression, as well as the adverse effects associated with systemic isotretinoin therapy.
Source link: https://doi.org/10.21203/rs.3.rs-1609874/v1
Acne vulgaris is a disease of the pilosebaceous unit that occurs regularly from 15 to 40 years. Essential oils can be used as an alternative therapy for AV. During AV therapy, this literature review explores the role of essential oils from kaffir lime, cinnamon, tea tree, lemongrass, oregano, or lavender.
Source link: https://doi.org/10.35335/midwifery.v10i4.764
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