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Acne - Springer Nature

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Last Updated: 05 December 2022

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A novel 1726-nm laser system for safe and effective treatment of acne vulgaris

The sebaceous glands' selective photothermolysis has the ability to be a safe alternative to acne vulgaris. We present the first FDA-approved device that uses a 1726-nm laser and advanced contact cooling to effectively treat mild, moderate, and severe acne while still ensuring safety and minimal patient discomfort without alternative pain relief methods. Combining laser energy and optimal contact cooling resulted in a dramatic temperature rise spatially restricted to the sebaceous gland, leading to highly targeted targeting and maximum injury to the sebaceous gland while preserving other skin structures. The simulation findings were corroborated by in vivo human facial skin histology results. The studies showed that the existing 1726-nm laser system promotes selective photothermolysis of the sebaceous gland, providing a safe and efficient treatment of acne vulgaris.

Source link: https://doi.org/10.1007/s10103-022-03645-6


Lasers for the treatment of erythema, dyspigmentation, and decreased elasticity in macular acne scars: a systematic review

Scarring is one of the most difficult and psychologically stressful aspects of inflammatory acne. Although the scar subtype with the least complicated outcome is u201cmacularu201d disease, its phase can be considered as the most defining in the ultimate scar appearance. We found the used lasers, namely neodymium-doped yttrium aluminum garnet, fractional carbon dioxide, pulsed dye, pro-yellow, and high-power optically pumped semiconductor, to be highly effective in treating the erythematous or dyspigmented appearance with the reduced elasticity significantly improving. The results from the nine included studies, according to the researchers, were primarily found to be extremely efficient in treating the erythematous or dyspigmented However, depending on the laser used, the degree of improvement each type of scar demonstrated following laser therapy differed. The most commonly investigated lasers for treating macular acne scars are those that use either erythema or dyspigmentation, according to Neodymium-doped yttrium aluminum garnet, fractional carbon dioxide, and pulsed dye, demonstrating eye-catching capabilities in coping with macular acne scars.

Source link: https://doi.org/10.1007/s10103-022-03621-0


Simultaneous Determination of 37 Anti-infective Drugs Potentially Illegally Added to Cosmetics that Claimed to have Anti-acne Effects by UHPLC-Q-TOF HRMS

In some cosmetics, illegal addition of anti-infective drugs has been found to cause rapid sterilization and anti-inflammatory properties. However, the use of anti-infective drugs could jeopardize citizens'''s health. A method combining ultra-high-performance liquid chromatography with quadrupole time-of-flight mass spectrometry was developed in this paper. U03bcg g'u22121 and u23121, respectively, with a score of 0. 0003 003-3 063 and u202121. The mean recoveries were in the range of 70. 1-u2013117. 7%, with matrix effects ranging from 73. 0 to 121. 4%. Of the 200 batches of cosmetics with anti-acne properties, three batches were positive, with chemical elements such as metronidazole, lincomycin, clindamycin, tinidazole, clindamycin, tinidazole, and miconazole nitrate being discovered. Therefore, the Q-TOF spectrometry could be widely used in routine screening of adulteration in cosmetics.

Source link: https://doi.org/10.1007/s10337-022-04206-3


The increasing importance of the gut microbiome in acne vulgaris

It has been reported that it is the loss of microbial diversity in the skin and the resulting imbalance among C. acnes phylotypes that causes acne rather than the C. acnes species as a whole. The gut microbiome of acne patients is implicated in overall health and physiology of the host, according to studies, the intestinal microbiome of acne patients is distinct and shows less microbial diversity than acne patients with less microbial diversity. In this light, future research should investigate the correlation between the gut microbiome and the agreed on causes of acne pathology, possibly leading to the development of novel acne treatment with less side effects.

Source link: https://doi.org/10.1007/s12223-022-00982-5


Treatment of Acne Vulgaris During Pregnancy and Lactation: A Narrative Review

Acne vulgaris is a common disease among women during pregnancy and lactation. During the various stages of pregnancy, hormonal and physiologic changes contribute to acne formation. Several common acne treatments are contraindicated during pregnancy or lactation. We summarize existing research on acne treatments during pregnancy and breastfeeding in this narrative review. Acne monitoring in pregnancy and lactation should take a stepwise approach based on severity to minimize risk.

Source link: https://doi.org/10.1007/s13555-022-00854-3


The hero of American and Polish nations: a molecular look at Thaddeus Kosciuszko’s cause of death suggests a contribution of endocarditis caused by Cutibacterium acnes infection

The estimated identifier of the P. acnes sequences and reference was 89 percentu201390% consistent with the theory that the identified reads represent the ancient P. acnes DNA, which underwent fragmentation and sequence changes owing to its long-time presence in the environmental conditions conducive to degradation. The analyzed results support a new and plausible argument that the bacteria in the original Kosciuszkou2019s heart tissue and that the C. acnes disease process was progressing inside the organ rather than on its surface, contributing to rapid health degradation and eventually death. Commensal, the primary skin acne treatment, can be associated with a variety of chronic skin disorders, posing a threat to health and life.

Source link: https://doi.org/10.1186/s12934-022-01970-7


Topical methylene blue nanoformulation for the photodynamic therapy of acne vulgaris

Acne vulgaris is a common skin disease caused by multifactorial factors involving increased sebum secretion and inflammation associated with Cutibacterium acnes. MBSD photoactivated MBSD demonstrated antimicrobial activity against C. acnes as well as long-term stability. When 24 patients with acne were treated with MBSD and light irradiation 5 times at 1-week intervals, MBSD-based PDT showed a dramatic decrease in acne lesions and sebum production as well as a 5-week intervals. Hence, MBSD is a promising topical PDT agent for biocompatible, safe, and effective acne treatment.

Source link: https://doi.org/10.1007/s00403-022-02464-7


Risk factors for the development of acne in healthcare workers during the COVID-19 pandemic

Many healthcare workers have continued contact with tight-fitting masks, resulting in maskne. acne secondary to mask use is identified as acne secondary to mask use, which is attributed to mask use. u201d Masknelu201d is the product of adequate acne. The aim of this report is to determine risk factors for the outbreak of maskne among healthcare workers. The most common mask styles worn at work were surgical masks and respirators. Maskne formation is based on the findings of this report, which reveal that gender and length of mask use are significant risk factors for maskne development.

Source link: https://doi.org/10.1007/s00403-022-02434-z


Extracellular electrons transferred from honey probiotic Bacillus circulans inhibits inflammatory acne vulgaris

B. circulans can ferment glucose to produce electricity and reduce the risks of human skin pathogens, according to this report. The glucoseu2013 B. circulans co-culture improved electricity production and dramatically reduced C. acne growth, according to the study. In a live experiment, the addition of roseoflavin to reduce flavin production greatly reduced the electrical energy generated by B. circulans by metabolism, and increased C. acnes count and macrophage inflammatory protein 2 levels. This means that B. circulans can produce electrons that influence C. acne formation and reduce the resulting inflammatory response by flavin-mediated electron exchange, as well as the resultant inflammatory reaction.

Source link: https://doi.org/10.1038/s41598-022-23848-9


Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris

Introduction Thirty-percent supramolecular salicylic acid, a modified salicylic acid formulation, is a safe and effective treatment for moderate-to-severe acne vulgaris. We wanted to investigate the effect of 30 SSA peels on skin microbiota and inflammation in patients with moderate to severe AV. Skin microbial samples and perilesional skin biopsies were obtained at the onset and 2 weeks after treatment ended. Patients After treatment, patients showed a significant improvement in their GAGS score and skin barrier indicators. The Propionibacterium proportion tended to decrease, as the richness and evenness of the cutaneous microbiome improved after therapy and the Staphylococcus proportion decreased dramatically. Conclusions We estimate that the 30 SSA peel may have a therapeutic effect in patients with moderate to severe AV by improving the skin microenvironment and modulating the skin microbiome, minimizing local inflammation.

Source link: https://doi.org/10.1007/s13555-022-00844-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions