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Severe acne vulgaris is a common chronic inflammatory skin disease worldwide. This research was designed to investigate the reasons of ALA-PDT's increasing acute inflammation in acne treatment. As a result, transcriptome microarray analysis of severe acne patients showed that ALA-PDT significantly up-regulated expression of several inflammation-related genes, especially TREM1 and PTGS2, which were later confirmed by a C. acnes-induced acne-like mouse ear model. In vitro and in vivo, the new experiments revealed that ALA-PDT may have triggered pro-inflammatory macrophage polarization of macrophages. In addition, the crosstalk between keratinocytes and macrophages tested by a transwell co-culture device showed that PGE2 secretly treated HaCaT cells in ALA-PDT treated HaCaT cells may contribute to THP-1 macrophages M1 polarization by COX2/PGE2/TREM1/treM1 axis to rise inflammation. It is hoped that this study will decipher the underlying mechanism of ALA-PDT for acne treatment as well as provide a theoretical basis for optimizing clinical ALA-PDT management.
Source link: https://doi.org/10.1016/j.bcp.2022.115403
A number of studies have show that 5-Aminolevulinic acid-based photodynamic therapy is clinically effective in treating acne vulgaris. PDT is recommended in several scientific studies on acne as an alternative treatment option for severe acne. Based on careful review of published research, expert opinions, and experience, the CMA and Photodynamic Therapy Rehabilitation Center of CARD's acne vulgaris, dermatologists, and PDT experts' application of ALA-PDT for acne vulgaris, dermatologists, and PDT experts developed consensus and guidelines on the use of ALA-PDT for acne vulgaris, dermatologists, and PDT experts from the Photodynamic Therapy Research Center of CARD's Photodynamic Therapy Rehabilitation Training Center of CARD's We reviewed and developed the recommended protocols for four PDT procedures, including conventional PDT, modified painless PDT, dramatic pulsed light PDT, and daylight PDT. M-PDT with lower ALA content, shorter incubation time, and lower dose are all recommended by Chinese dermatologists, but prolonged exposure can significantly reduce moderate to severe acne vulgaris lesions with less pain and quicker manipulation.
Source link: https://doi.org/10.1016/j.pdpdt.2022.103261
The transcriptomic regulation triggered by isotretinoin is still a topic of debate, as short-term exposures of immortalized sebocytes with isotretinoin resulted in contradictory results. For six weeks, twenty-five patients suffering from acne vulgaris were treated with isotretinoin. Quantitative reverse transcription real time PCR showed that p53 expression was determined by immunohistochemical staining, quantification of p53 protein content by enzyme-linked immunosorbent assay, and TP53 gene expression by quantitative reverse transcription real time PCR. Compared to pre-treatment and p53 levels in untreated controls, Isotretinoin therapy dramatically raised the nuclear expression of p53 in sebaceous glands of patients treated patients. According to the severity of acne severity score and body mass index, the magnitude of p53 expression indicated an inverse relationship. The underlying transcriptomic changes behind sebum suppression, as well as systemic isotretinoin therapy, are explained by increased p53-FoxO1 signalling stimulated by systemic isotretinoin therapy, but also the adverse effects of systemic isotretinoin therapy.
Source link: https://doi.org/10.1007/s00403-022-02508-y
Three board-certified dermatologists developed a virtual tour on skin care, acne treatment, and acne-associated stigma among adolescents to raise acne health literacy among adolescent youth in order to improve acne health literacy. About half of all students thought acne should not be treated with medications, while only 34. 0% agreed acne could impact their mental stability, and the majority of students incorrectly believed that dirt buildup and poor hygiene were causeable for acne.
Source link: https://doi.org/10.1111/pde.15230
The acne vulgaris most noticeable is the front of individual and chest and back of individual is also affected sometime. The aim of my study is to determine the effectiveness of topical adapalene plus oral doxycycline in treating acne. Acne is one of the most common reasons requiring a patient to seek dermatological assistance.
Source link: https://doi.org/10.55519/JAMC-04-9568
In the treatment of facial atrophic post-acne scars, this research seeks to compare the effectiveness and safety of combined subcision using fractional CO2 laser or cross-linked hyaluronic acid filler or subcision alone. The percentage of patients with excellent growth in group 1 and group 2 was higher in group 1 and group 2 than in group 3 with p value = 0. 031, according to the mean percentage of decline in quantitative grading, which was higher in group 1 and group 2 than in group 3 with a p value of 0. 031, relative to group 3 with p value 0. 00. Both subcision with fractional CO2 laser or cross-linked HA filler provided superior results in facial atrophic post acne scars treatment with no adverse side effects in this research.
Source link: https://doi.org/10.1007/s10103-022-03677-y
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