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Aims were to assess the insulin resistance and adipsin levels in serum and saliva in a sample of acne vulgaris patients; and to compare IR and adipsin levels with disease severity. According to the Global Acne Grading System, the severity of acne vulgaris was determined. Patients' adipsin and Quantitative insulin sensitivity check index were reduced than the control group's. Adipsin serum measurements reveal strong negative correlations with all study variables except QUIKI, where the correlation was positive both in serum and saliva. serum and salivary adipsin levels, as well as serum and salivary fasting glucose were found to have a significant positive relationship. Conclusions In conclusion, Adipsin has been regarded as a promising biomarker for acne vulgaris and its associated insulin resistance.
Source link: https://europepmc.org/article/MED/36459421
Background treatment with filler injections using a microneedle fractional radiofrequency unit is a promising technique for acne scar treatment with demonstrated safety for acne scar treatment. Both cheeks were affected by acne scars on both cheeks. 2 patients underwent a skin biopsy from the upper arm before and after the same single session. Conclusion Intradermal injection of PDLA using the MFRF device may be able to be used as an effective therapy with less side effects in acne scar patients with Fitzpatrick skin type III-IV.
Source link: https://europepmc.org/article/MED/36449872
During pregnancy and lactation, Acne vulgaris is a common cause of women. During the various stages of pregnancy, hormonal and physiological changes may have contributed to acne pathogenesis. Several common acne treatments are contraindicated during pregnancy or lactation. We summarize existing research on acne treatments during pregnancy and breastfeeding in this narrative review. Acne prevention in pregnancy and lactation should take a stepwise approach based on severity to minimize risk. In these special populations, this paper provides updated reference to support patient-physician decision-making on acne management in these special populations.
Source link: https://europepmc.org/article/MED/36447117
Background Scarring is a common and painful symptom of acne vulgaris acne vulgaris. There are no approved topical creams for acne scar therapy. Unique ingredients, Kollaren and Exo-T, form the investigational product, acne scar serum, is the most recent topical formulation for acne scar treatment. Objectivise Evaluate the safety and efficacy of new acne scar serum on the reduction of acne scars in Indian populations. At both visits compared to baseline, significant improvements in mean acne scar depth, mean acne scar volume, and mean L value were all present, as opposed to baseline. Conclusions We found that there was a significant decrease in acne scar and post-acne pigmentation using a monotherapy with new acne scar serum, but that needs further confirmation in larger random controlled studies. So, topical acne scar serum with unique ingredients Kollaren and Exo-T can be a safe, convenient, and a new option in the acne scar serum arsenal.
Source link: https://europepmc.org/article/MED/36437741
Oral isotretinoin is the most common treatment technique for acne patients. This research was designed to determine hematologic abnormalities during oral isotretinoin therapy in acne patients. Methods and methods In this cross-sectional study, the hematologic and inflammatory profiles of 138 patients with acne treated with 0. 3-1 mg/kg/day oral isotretinoin for at least six months were retrospectively reviewed. Conclusions The female-to-male ratio in the study was 2. 83, while the mean age of the patients was 23. 1 u00b1 5. 8 years. The neutrophil count decreased by 27% in the third and sixth months of isotretinoin therapy, relative to the pre-treatment values. No significant changes were made in hemoglobin, hematocrit, white blood cell count, mean corpuscular volume, and mean platelet volume. However, it would be necessary to track blood counts during care in patients with neutropenia or thrombocytosis.
Source link: https://europepmc.org/article/MED/36437707
Acne vulgaris is the eighth most common disease worldwide and it appears in inflammatory and noninflammatory skin lesions as well as other dermal abnormalities. Due to its antiandrogenic properties and inhibition of sebogenesis, Oral spironolactone is used for treating acne vulgaris. Spironolactone in topical form has similar safety to its oral counterpart, despite the fact that there are few adverse events connected with its use, according to new reports. In each study, the Cochrane risk of bias assessment system was used to determine the likelihood of bias. Although the acne severity index was still high, 2% spironolactone demonstrated efficacy over clindamycin and reduced the number of comedones, papules, and pustules, as well as pustules. Topical spironolactone gives more results than other first-line acne treatments and has less side effects. However, further large-scale clinical trials are required before spironolactone can be used as the recommended treatment for acne management.
Source link: https://europepmc.org/article/MED/36412248
Background, cleansing, moisturizing, and photoprotection are four main elements of holistic skin care for dermatological disorders. The main barriers to creating a holistic skin care regimen for dermatological disorders are limited patient awareness, product confusion, and a lack of information on how to choose and use CMP skin care products. Aims This research sought to evaluate current clinical evidence, identify gaps, and give practical recommendations on the conceptualization and implementation of CMP strategies in the management of sensitive skin caused by underlying acne, atopic dermatitis, or rosacea, as well as conditions with idiopathic skin syndrome. Conclusions A dermatologist-guided holistic skin care regimen is critical to increase patient satisfaction and reduce confusion regarding product choice.
Source link: https://europepmc.org/article/MED/36409588
Impulsivity is one of the key signs of many psychiatric disorders. Aims This study was conducted to investigate the relationship between acne excoriee and various impulsivity traits. Methods Thirty patients with acne excoriee and 30 acne vulgaris patients without excoriated lesions were included in this research. The Barratt Impulsivity Scale assessed Impulsivity, a new measure of motivation. In addition, the Beck Anxiety Inventory, The Beck Depression Inventory, and The Skin Picking Scale were used to determine the participants's medical characteristics. In this research, AE+ patients had higher non-planning subscale scores of BIS than AE-patients. In addition, the acne-picking severity score calculated by The Skin Picking Scale was positively associated with non-planning BIS scores. The Beck Depression Inventory and Beck Anxiety Inventory showed that there were no significant differences between the two groups. These findings reveal that AE patients have a lack of forethought.
Source link: https://europepmc.org/article/MED/36409553
This research was conducted retrospectively to determine the efficacy and pleasure of combined FCL and FRFL treatments for acne scars, as well as the effect of these therapies particularly on atrophic scar types. In this research, a total of 41 patients with acne scars who had FCL + FRFL were included. According to the ECCA acne scar scoring system, patient photographs before and 1 month after the last therapy session were scored by one blinded physician. In conclusion, our results showed that laser therapy for acne scars is safe, convenient, and convenient.
Source link: https://europepmc.org/article/MED/36403157
Skin texture improvement has been praised for skin texture, with pore reduction and acne lesion treatment, according to a report. Even if this research is limited by the limited number of patients and its retrospective nature, this is the first study to show that carbon peel laser, applied by a standard procedure, is a safe and effective treatment for patients with acne lesions, including pores and wrinkles, and it can also improve the overall skin appearance.
Source link: https://europepmc.org/article/MED/36422207
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