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The present research was done to determine and investigate the antibacterial properties of Rhizophora stylosa fruit extract. By disc diffusion method, the antibacterial activity of R. stylosa crude extract was tested against Staphylococcus epidermidis, Staphylococcus epidermidis, and Propionibacterium acnes. The extract had a minimum inhibitory concentration value of 0. 05 mg/ml against S. aureus and P. acne, as well as 0. 1 mg/mL against S. epidermidis. The extract's 0. 55 w/w of the All herbal gel formulations demonstrated a strong inhibitory activity against P. acnes. With 0. 5% kappa carrageenan and 0. 55 percent Carbomer 940, the optimized formulation was considered as the most effective formulation among all formulations tested. Acne vulgaris is a common disease that can be resistant to gel formulations, according to the writer. The safety and effectiveness of R. stylosa can be determined by further research before determining whether or not it is an effective natural anti-acne agent.
Source link: https://doi.org/10.12928/pharmaciana.v12i3.21942
In treating acne vulgaris, we wanted to determine the eficacy of Tazarotene 0. 1% cream versus Clindamycin 1% gel. Patients in both groups used one-fourth fingertip unit of Tazarotene 0. 1% cream in the evening once daily and Clindamycin 1% gel over the affected area in the morning for 12 weeks. Topical Tazarotene cream was more effective than topical Clindamycin 1% gel, with a p-value less than 0. 01. Conclusion: In treating acne vulgaris, topical Tazarotene cream was more effective than topical Clindamycin 1% gel.
Source link: https://doi.org/10.51253/pafmj.v72i5.6764
Objective: To determine the safety of intradermal platelet-rich plasma with 30% Trichloroacetic acid in treating atrophic acne scars. The study included 76 patients with atrophic acne scars in total. Patients in the Plate rich plasma Group were nigh to 29. 63 years and 29. 92 years, according to the 30% Trichloroacetic acid Group, a mean age of patients in the Plate rich plasma Group was 29. 63 years and 29. 82 years. Platelet Rich Plasma was an effective treatment of atrophic acne scar tissue in the Goodman and Baron quantitative acne scar scale, with post-procedure improvement. Conclusion: With intradermal Plate-rich plasma, an atrophic acne scar treatment is more effective than 30% Trichloroacetic acid.
Source link: https://doi.org/10.51253/pafmj.v72i5.7627
The oil phase titration method and optimized by pseudo-ternary phase diagrams blended eucalyptus oil, Tween 20, and Transcutol HP, along with Tween 20, and Transcutol HP. Ex vivo skin permeation experiments were conducted with Franz diffusion cell using rat skin as the permeation membrane, and the nanoemulgel demonstrated sustained-release behavior, to determine the extent of drug penetration between nanoemulsion and nanoemulgel. It can be expected that the suggested minocycline-containing naoemulgel would be used to treat acne rosacea more effectively.
Source link: https://doi.org/10.3390/pharmaceutics14112322
Skin texture has been improved with skin peel laser therapy, which has pore reduction and acne lesion treatment, as well as acne lesion treatments. Even if this research is limited due to the poor number of patients and its retrospective nature, this is the first study to show that carbon peel laser, which are administered with a standardized method, is an effective and safe therapy for patients with acne lesions, showing pores and wrinkles, as well as the overall skin condition.
Source link: https://doi.org/10.3390/medicina58111668
Acne vulgaris is one of the most common dermatological disorders in children and adults in Saudi Arabia's Kingdom. Compared to other methods used for severe acne treatment, Isotretinoin is a cost-effective way of treating severe acne patients. The present research investigated the use of isotretinoin and its side effects among female acne patients of the reproductive age group who were on isotretinoin. SFDA-PPP was significantly higher among those working in health-care industries. Conclusion: The current survey found that there were insufficient numbers among female acne patients of the reproductive age group regarding isotretinoin use, precautions, and side effects, particularly teratogenic effects. This research shows that increasing female acne patients's isotretinoin exposure through health promotion activities is crucial, especially by giving them clearer information about the teratogenic effects.
Source link: https://doi.org/10.3390/medicina58111609
Background: Atrophic acne scarring is uncomfortable and often permanent problem for dermatologists and a therapeutic challenge for dermatologists. Platelet-poor plasma gel injections are made from the patient's own blood and used as a 'u201cbiofiller'u201d for skin rejuvenation. Objectives: The aim was to determine the efficacy and safety profile of PPP gel in atrophic acne scars. Patients with atrophic acne scars were included in the study, according to the Materials and Methods: In the analysis, thirty patients with atrophic acne scars were included. To get PPP that is coagulated with heat to form gel, eight sodium citrate bulbs were collected and centrifuged. Variation tests were used from baseline to final visit on the quantitative scale from baseline visit to final visit. For the GBS quantitative scale, paired t-test was used, resulting in a score of 22. 86 with a P value of 0. 001. Biofiller's action in reducing atrophic acne scars is highly recommended.
Source link: https://doi.org/10.4103/JCAS.JCAS_58_22
Aim: To determine the identity of acne keloidalis nuchae among N. . . . ians and to record the various treatment options used by these patients prior to their dermatology clinic visit. Patients with acne nuchae were enrolled in the University of N. . . . ia Teaching Hospital Enugu from 1993 to 1998, and a retrospective review of patients with acne keloidalis nuchae was carried out. 203 out of 7. 861 new patients with skin disorders diagnosed within the study period had AKN, with a remark that was 203 out of 203 out of 7. 861 new patients with skin diseases classified within the study period. In addition, irregular menstrual cycles and infertility, three of the three affected females had irregular menstrual cycles and infertility. 63. 2% eruptions occurred in 63. 2% in the Lesions, while the lesion's were already fibotic with keloid-like papules/plaques in 76. 3%. Obseque keloidalis nuchae in N. . . . ians is similar to that described in western literature, except for a substantial number of males who were present at the fibrotic phase with massive keloids first.
Objective: The aim of this research was to explore serum irisin as an adipokine's role in AV's pathogenesis and its relationship with IR, as well as whether it can be used as a potential insulin sensitivity biomarker.  Given that an inexpensive and quick serum biomarker is an attractive and simple way for the prediction and diagnosis of IR, clinicians may be able to provide clinicians with a more accurate and convenient method for the diagnosis of IR. IR can often be detected before other signs appear, so finding an early diagnosis system will ensure the right treatment of patients even before the disease develops. Patients and Methods: The study included 171 patients; 115 patients with newly diagnosed AV and 56 apparently healthy subjects; and 56 apparently healthy subjects. By enzyme-linked immunosorbent assay, the contents of irisin and interleukin-1 alpha in serum were determined by enzyme-linked immunosorbent assay. The homeostasis model estimated the IR index. Results: The serum irisin levels in AV patients and control group were and ng/dl, respectively, which were significantly lower than those in the control group. Serum irisin was not positively linked to IR in a negative manner, according to IR. The sensitivity of irisin was 100 percent, the specificity was 92. 8%, and the cutoff point was 53. 32. A decrease in serum irisin level can help identify patients with acne-resistant IR. Conclusion: The occurrence of smuo irisin levels in AV patients had significantly decreased. In the diagnosis of AV with IR, Serum irisin met acceptable performance standards. Serum irisin seems to be a good diagnostic and prognostic marker for IR.
Source link: https://doi.org/10.4103/ijd.ijd_251_22
This research investigated whether B. circulans could ferment glucose to produce electricity and minimize human skin pathogens' effects. B. circulans' electrical energy production by metabolism was greatly reduced by roseoflavin, inhibiting flavin production, and, in a vivo experiment, C. acnes count and macrophage inflammatory protein 2 levels were found to be in vivo. This means that B. circulans can provide electrons that influence C. acne formation and minimize inflammatory response by flavin-mediated electron exchange, as well as decreasing the resultant inflammatory response.
Source link: https://doi.org/10.1038/s41598-022-23848-9
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