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Iotretinoin, Orally administered is now the only drug that can influence all four key factors that have been attributed to acne. IGF-1 also stimulates androgen synthesis, which results in sebum overproduction. Propionibacterium acne can increase the production of serum amyloid A1 in patients with acne, with a positive correlation with its severity. Acne is caused in large part by the emergence of reactive oxygen species in response to infection by the bacterium Propionibacterium acnes, which colonizes the skin and increases in plugged hair follicles, thereby providing inflammatory cells, mainly neutrophils. Silymarin, the key active component of milk thistle, is made up of a blend of flavonolignans and flavonoid taxifolin. Silymarin acts as a free radical scavenger, stabilizes the plasma membrane, minimizes the production of inflammatory mediators used by P. acnes, and reduces the production of inflammatory mediators that can be produced by P. acnes.
Source link: https://clinicaltrials.gov/ct2/show/NCT05666765
Acne is a chronic disease that often requires the use of several medications and often declines over time, especially for those using topical medications. 1 Nonadherence can result in a variety of adverse effects, including treatment failure, increased healthcare costs, and reduced quality of life.
Source link: https://clinicaltrials.gov/ct2/show/NCT05582434
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