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Acinic cell carcinoma is a common salivary gland malignancy, composed of neoplastic acinic cells with zymogen granules. The study included eighty-five classic low-grade ACiCC cases, as well as 36 cases of high-grade change and seven high-grade AciCC cases. In addition, this is the first report of an NR4A2 rearrangement being identified by FISH in two AciCC cases that were unresponsive for the NR4A3 rearrangement. The majority of AciCC are immunopositive for NR4A3, including high-grade cases and cases with HGT, are immunopositive for NR4A3, according to our analysis, NR4A3 immunohistochemistry is a powerful tool in the differential diagnosis of salivary gland tumors. AciCC may also be negative for NR4A3 immunostaining in a minority of cases, according to our report, because the pathogenic genetic event in these cases is a reversion of the NR4A2 gene.
Source link: https://europepmc.org/article/MED/36469101
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