Advanced searches left 3/3

Acidosis - PubMed

Summarized by Plex Scholar
Last Updated: 27 July 2022

* If you want to update the article please login/register

A case of severe acidosis in a 12-month-old: Succinyl-CoA:3-ketoacid-CoA transferase deficiency with OXCT1 gene mutations.

Succinyl-CoA's deficiency is a rare autosomal recessive disorder that results in severe ketoacidosis due to a defect in ketone utilization. We'll explain our immediate care unit's initial stabilization procedures as well as our solution to preventing morning ketosis after discharge using uncooked cornstarch.

Source link: https://doi.org/10.1177/2050313X221111274


Lactic acidosis and hypoglycemia as markers of disease progression of multiple myeloma: A case report.

Case report: A 64-year-old man was hospitalized in the intensive care unit with pneumonia, lactic acidosis, and hypoglycemia. Multiple myeloma were found on investigation. With a normalization after chemotherapy, there was a correlation between the evolution of the myeloma, serum lactate level, and hypoglycemia, as well as a rise at myeloma's relapse. The patient died 4 months and ten days after his first hospital admission. Within one year, there had been 91 confirmed cases of myeloma type B lactic acidosis. Conclusion: Multiple myeloma is correlated with disease development and has a high mortality rate. Symbols of Significance : A metabolic shift to increased glycolysis activity in malignant cells can be experienced in several myeloma, as well as the Warburg effect.

Source link: https://doi.org/10.1002/jha2.176


Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming.

Mitochondrial diseases are a heterogeneous group of rare genetic disorders related to mutations in nuclear or mitochondrial DNA. Mutations in mitochondrial transfer RNA contribute to protein translation defects that can affect some or all mtDNA-encoded proteins. For the first time, we show a successful direct conversion of MELAS patient-derived fibroblasts into induced neurons, as well as an electrophysiological analysis of iNs cocultured with astrocytes. In addition, we did bioenergetics analysis to determine the consequences of the m. 3243A > G mutation in this neuronal model of MELAS syndrome.

Source link: https://doi.org/10.1089/cell.2022.0055


Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease.

Due to a lack of biopsy tissues from patients with DKD and the intricate mechanism of lactate homeostasis, the relationship between changes in renal lactate metabolism and renal fibrosis in diabetic patients with diabetes has only been partially established. Patients with DKD were highly negatively correlated with measures of lactate metabolism and DKD progression. DKD patients with local acidosis caused by renal LDHA should be investigated further to see if local acidosis caused by renal LDHA can be exploited as a therapeutic target.

Source link: https://doi.org/10.1016/j.trsl.2022.06.015


D-Lactic Acidosis in Short Bowel Syndrome.

Short bowel syndrome is closely related to D-lactic acidosis. We explore the case of a 43-year-old man with Crohn's disease and bowel resection who presented with abdominal pains and slurred speech in this article. When treating patients with bowel transplantation and unexplained AGMA, a high risk of D-LA should be maintained.

Source link: https://doi.org/10.7759/cureus.25471


Weighted Gene Co-expression Network Analysis Identifies Specific Modules and Hub Genes Related to Subacute Ruminal Acidosis.

Weighted gene co-expression network analysis was used to determine the pathogenesis of subacute ruminal acidosis and find potential genes related to the disease. Data from dataset GSE143765, which included 22 cows with and nine cows without SARA, were downloaded from NCBI Gene Expression Omnibus, which included 22 cows with and nine cows without SARA. DCXR mainly displayed L-xylulose reductase activity, glucose metabolic process, xylulose metabolic pathway, and carbonyl reductase reduction, according to functional analysis, which is key to the pentose and glucuronate interconversion pathways. MMP15 and MMP17 are mainly due to a collagen catabolic process.

Source link: https://doi.org/10.3389/fvets.2022.897714


Heart rate markers for prediction of fetal acidosis in an experimental study on fetal sheep.

Several tools based on the autonomic nervous system and heart rate variability have been developed to solve the challenges in determining fetal heart rate variability. The aim of this research was to use FHR and HRV methods for the prediction of fetal hypoxia. The fetal arterial pH was the gold standard used to classify hypoxia. A total of 130 pairs of FHR/fetal pH measurements were obtained, 29 in the acidosis group and 101 in the non-acidosis group. Considering a threshold of 68, the AUC of FSI alone in this model was 0. 81, with a sensitivity of 0. 66, ppV of 0. 61, and an NPV of 0. 90. Both CHAID and CART algorithms had a sensitivity of 0. 48 and 0. 59, respectively, with a specificity of 0. 94 for both. It's not surprising that FHRV-based FHRV technologies for the assessment of fetal acidosis during labor.

Source link: https://doi.org/10.1038/s41598-022-14727-4

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions