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Acidosis - Europe PMC

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Last Updated: 27 July 2022

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Invited review: Effect of subacute ruminal acidosis on gut health of dairy cows.

Subacute ruminal acidosis is thought to be a common disease among high-yielding dairy cows. The prevalence of SARA has been mostly determined by measuring the pH of ruminal fluid obtained using rumenocentesis. SARA's signs are not limited to ruminal pH depression, and ruminal pH varies among sites in the rumen during a 24-h period and days, but it may not be truly accurate. SARA has mostly been investigated by performing SARA experiments in cows, sheep, and goats based on a combination of feed restriction and high-grain feeding. Gut health is influenced by Grain-based SARA challenges. At the phylum level, changes in the taxonomic composition of gut microbiota throughout the GIT are apparent, but more subtle and more variable at the genus level. More studies on the effects of a SARA challenge on gut microbiota's functionality are required. The inflammatory response that has arisen from grain-based SARA challenges is both acute and moderate, and it mostly comes from an acute phase response. Severe SARA can cause rumenitis, but moderate SARA can spark an immune response in the GIT's epithelia. Cows grazing high-sugar pastures with high sugar content may also have a low ruminal pH indicating SARA. Many aspects of gut health are affected by grazing high-digestible pastures and insufficient coarse fiber, but not so much so.

Source link: https://europepmc.org/article/MED/35879171


Distal renal tubular acidosis presenting with an acute hypokalemic paralysis in an older child with severe vesicoureteral reflux and syringomyelia: a case report.

Background Distal renal tubular acidosis is the most common form of renal tubular acidosis in children. Pediatric dRTA is usually genetic, and rarely occurs due to conditions such as obstructive uropathies, recurrent urinary tract infections, and chronic kidney disease. Although persistent hypokalemia is common with dRTA, acute hypokalemic paralysis is not commonly reported, especially in older children. Although persistent hypokalemia is common in chronic hypokalemia is not common, acute hypokalemic paralysis is not common. Case study An eight-year-old girl was born with an acute first episode of paralysis. She also had a 1. 9 mOsmol/kg urine osmol/kg urine pH, which caused a high urine pH. Conclusions This case study points out the importance of considering dRTA in the differential diagnosis of hypokalemic acute paralysis in children. In addition, early diagnosis of spinal cord dysfunction and recurrent UTIs in children with neurogenic lower urinary tract disease (RTU) is critical to treat quickly, minimize CKD progression, and avoid long-term problems such as RTA.

Source link: https://europepmc.org/article/MED/35836135


A case of severe acidosis in a 12-month-old: Succinyl-CoA:3-ketoacid - CoA transferase deficiency with OXCT1 gene mutations.

Succinyl-CoA deficiency is a rare autosomal recessive disorder that results in severe ketoacidosis as a result of a defect in ketone utilization. Deficiency at our institution was the first recorded case of SCOT deficiency. We outline our immediate care unit's initial stabilization methods, as well as our solution to preventing morning ketosis after discharge using uncooked cornstarch.

Source link: https://europepmc.org/article/MED/35847427


Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming.

Mitochondrial diseases are a heterogeneous group of rare genetic disorders due to mutations in nuclear or mitochondrial DNA. Mutations in mitochondrial transfer RNA cause protein translation defects that may include some or all mtDNA-encoded proteins. For the first time, we show a successful direct conversion of MELAS patient-derived fibroblasts into induced neurons, as well as an electrophysiological analysis of iNs cultured with astrocytes. In addition, we did bioenergetics analysis to determine the consequences of m. 3243A> G mutation in this neuronal model of MELAS syndrome.

Source link: https://europepmc.org/article/MED/35802497


Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease.

Because of a shortage of biopsy tissues from patients with DKD and the intricate process of lactate homeostasis, the relationship between changes in renal lactate metabolism and renal fibrosis in diabetic patients with diabetes has only been partially established. In patients with DKD, measures of lactate metabolism and DKD progression were highly negatively related. Patients with DKD may be interested in investigating whether local acidosis caused by renal LDHA may be exploited as a therapeutic target.

Source link: https://europepmc.org/article/MED/35788054


Molecular Aspects of Distal Kidney Tubular Acidosis in Children, Its Long-Term Outcome, and Relationship with Hyperammonemia.

Objective We wanted to present the characteristics, genetic analysis findings, long-term prognosis of our patients with distal kidney tubular acidosis, and the relationship between hyperam-monemia and distal kidney tubular acidosis. At presentation and in 3 in the last clinic visit, height standard deviation scores were less than -2 in 4 patients at presentation and in 3 at the last clinic visit. All our patients had nephrocalcinosis and hypercalciuria at the time of diagnosis, but only 1 patient had hypercalciuria at the last visit. Sensorineural hearing loss was present in 4 of our patients with a mutation in the ATP6V0A4 gene. In 3 patients with mutations in the ATP6V0A4 gene, serum ammonia levels were found to be elevated. In distal kidney tubular acidosis patients, adequate metabolic control is key to optimal growth and intact kidney function. Hyperammonemia can cause distal kidney tubular acidosis.

Source link: https://europepmc.org/article/MED/35822476

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions