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Background: Running a marathon has shown elevated T2 and T1u03c1 values on magnetic resonance imaging after running a marathon, with the most significant changes in the patellofemoral and medial compartment, which can persist after 3 months of reduced activity. In addition, marathon running has been shown to raise serum inflammatory markers. The aim of this research was to see if intra-articular HA injection would shield cartilage from damage related to marathon running. The hypothesis was that intra-articular HA addition 1 week before running a marathon would reduce the severity of early cartilage damage measured by MRI. Within 48 hours before the marathon, a Baseline 3-T knee MRI was obtained within 48 hours. In 8 locations, the medial and lateral compartments, and the patellofemoral joint were measured, with the T2 and T1u03c1 relaxation times of articular cartilage. Changes in T2 and T1 relaxation times from baseline to immediate and 3-month postmarathon scans were compared between the HA and NS groups with repeated measures analysis of variance. Fifteen runners finished the report: Six women and two men in the HA group, 6 women and 2 men in the NS group, and 6 women and 1 man in the NS group all completed the experiment: five women and 2 men in the HA group, six women and 2 men in the HA group, and 6 women and 1 man in the NS group completed the survey. On both T2 and T1u03c1 relaxation times, no statistically significant changes were found between the HA and NS groups in any of the knee joint cartilage areas of articular cartilage. Conclusion: In marathon runners, T2 and T1-u03c1 relaxation times have been increased, indicating early cartilage damage.
Source link: https://doi.org/10.1177/0363546519879138
In a cohort of patients with RC tendinopathy related to gender differences, the aim of this research is to determine the responses in two different therapeutic rehabilitative techniques, the combined treatment of ESWT plus hyaluronic acid injections, compared to ESWT alone. Patients who had undergone a medical examination, a shoulder ultra sound examination, the Shoulder Pain and Disability Index questionnaire, and the Numerical Rating Scale for pain at baseline were included in this report. Patients in the E + Hy group in comparison to the ESWT-al group's findings showed modest but statistically significant declines in both NRS and SPADI scores, although these changes were more noticeable at T2. Both genders' retrospective cohort study shows that ESWT plus HyA injections may be more cost-effective than ESWT alone in RC tendinopathy.
Source link: https://doi.org/10.1186/s12891-022-05819-3
Abstract Background: The new treatments in hip osteoarthritis management include an intraarticular injection of platelet-rich plasma and hyaluronic acid. In patients with hip OA, the aim of this report was to compare the safety of IA injections of PRP, HA, and their combination in patients with hip OA. Both HA and PRP are two IA techniques that can be used in OA in the preoperative stages. Patients with grade 2 and 3 hip OA were included in this study and were randomly divided into three injection groups: PRP, HA, and PRP + HA. In the PRP + HA and PRP groups' comparison to the HA group, significant differences between the three groups revealed substantial differences regarding WOMAC and Lequesne total scores and the daily life subscale of Lequesne, which indicated significant improvement in the PRP+ HA and PRP groups in comparison to the HA group. Conclusion In the long run, PRP and PRP + HA injections treated pain and function in patients with hip OA, but the clinical effects of these three interventions on patients with hip OA were superior to HA in terms of pain and function, as well as mobility, and ADL in patients with hip OA. Moreover, the addition of HA to PRP did not result in a significant rise in the therapeutic results. Trial registration (IRCT20130523013442N30), September 29, 2019 The research was published on the Iranian Registry of Clinical Trials website http://www. irct. ir/, a WHO Primary Register system based in Tehran, with the registration number IRCT20130523013442N30.
Source link: https://doi.org/10.1186/s12891-022-05787-8
Purpose: To evaluate knee degenerative disease clinical outcomes after intra-articular injections of either PRP or hyaluronic acid. Patients with a history of persistent knee degenerative changes and osteoarthritis were enrolled in 192 patients' randomised intra-articular injections of either PRP or HA. Both drugs were able to raise knee functional status and symptoms with time, according to the mean u00b1 SDIKDC subjective score, which remained stable after 24 months. At the end of the study, a significant IKDC decrease was observed in both treatment groups, with the PRP group showing significantly higher figures than baseline: PRP 60. 5, HA 55. 7 u00b1 18. 8. Patients' subjective experience of symptomatic relief was 9 months for HA and 12 months for PRP.
Source link: https://doi.org/10.1177/0363546518814532
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