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Despite limited scientific evidence and conflicting global recommendations on its use, hemoglobin injections remain a common nonsurgical option for knee osteoarthritis surgery. Methods We customized Google Trends to gather search results from January 2009 to December 2019 in both the United States and Europe. As time progressed, Google queries regarding hyaluronic acid for knee injections in both the United States and Europe increased. The models, which were designed to demonstrate public interest in hyaluronic acid for knee injections in knee injections in both the United States and Europe, increased Google queries as time progressed. The United States growth model reflected linear expansion, while the European growth model displayed exponential growth. Conclusions Our results show a significant rise in Google queries relating to hyaluronic acid injections for knee osteoarthritis since 2009 in both the United States and Europe. Given mixed evidence supporting its use, orthopedic surgeons should continue to use hyaluronic acid for knee osteoarthritis, according to our models.
Source link: https://europepmc.org/article/MED/36353188
Despite limited scientific data and conflicting international guidelines regarding its use, hyaluronic acid injections remain a common nonsurgical alternative for knee osteoarthritis treatment. In both the United States and Europe, we modified Google Trends parameters to get search results from January 2009 to December 2019. Results The models created to describe public interest in hyaluronic acid for knee injections in both the United States and Europe increased Google queries as time progressed. The United States growth model displayed linear growth, while the European growth model demonstrated exponential growth. Conclusions In both the United States and Europe, our results show a significant rise in Google queries related to hyaluronic acid injections for knee osteoarthritis since 2009. Given mixed evidence pointing to its use, orthopedic surgeons should continue to use hyaluronic acid for knee osteoarthritis, according to our models.
Source link: https://europepmc.org/article/MED/PMC9638715
Both pro- and anti-OA effects can be produced by extracellular vesicles secretly produced by synovial joint cells. Hyaluronic acid lubricates the surfaces of articular cartilage and is one of the bioactive substances transported by EVs. Changed EV numbers and composition can be found in OA synovial fluid, while EV studies are in the beginnings of the horse's highly recognized OA model. In 19 horses, the aim was to identify SF EVs and their HA cargo. HA-EV count, total EV count, and HA-EV percent were all correlated with the OA grade, but not HA-EV count, and HA-EV percent, respectively. The total HA concentrations were also lower in OA. To summarize, the present study revealed a potential SF biomarker for naturally occurring equine OA. Future research is warranted due to the contributions of HA-EVs in the pathogenesis of OA and their potential as a joint disease biomarker and therapeutic target.
Source link: https://europepmc.org/article/MED/36266410
In knee OA in Kellgren-Lawrence grade 3 and 4 knees, the new approach to knee OA falls short of completely halting disease progression, particularly in Kellgren-Lawrence grade 3 and 4 knee OA. After arthroscopic debridement in KL grade 3 and 4 knee OA, Aim To investigate the effects of adjunctive platelet rich plasma and hyaluronic acid. Results From before diagnosis to 3 mo and 5 mo after therapy, all three treatment groups showed significant improvements in WOMAC scores and sub-scoring from before and after treatment. However, the arthroscopic debridement group, in particular, had a significantly lower WOMAC pain score than the group that received arthroscopic debridement alone at 5 mo after the procedure. Conclusion Compared to arthroscopic debridement alone, adjunctive PRP after arthroscopic debridement considerably reduced the patients' pain symptom.
Source link: https://europepmc.org/article/MED/36312525
In surgically nave patients with knee osteoarthritis na na's knee osteoarthritis, this pilot study examined the safety of autologous bone marrow-derived mesenchymal stem cells against hyaluronic acid. With a 38. 0% decrease in 6 out of 10 BM-MSC participants, the first time in the BM-MSC group's T-relaxation time tended to decrease in 6 out of ten BM-MSC participants, while the first HA participants's T2-relaxation time in the BM-MSC group was down by 8 percent, with a 12 bb1 0u00b1 u200b7. 9% decrease in 8 out of 10 out of a u200b1 u200b20b1 a u200b1 a u200b1u200b24. This article's translational value The feasibility and potential of BM-MSC's enhanced therapy for patients with knee OA compared to HA injections was demonstrated by this pilot RCT. A long-term safety and efficiency of MSCs therapy for cartilage regeneration in OA are warranted by a larger sample size and longer follow-up period in accordance with the new regulatory standards.
Source link: https://europepmc.org/article/MED/36262962
Regardless of leukocyte concentration, VAS demonstrated significant improvement in pain according to the VAS score compared to HA at 6 and 12 months. Both single and multiple injections of PRP improved pain at 12 months's disability and were safer than HA at 12 months. There was no significant difference between the PRP and HA groups in terms of surgical-related knee pain or swelling. Compared to the HA, Leukocyte-rich PRP had a significantly higher odds ratio for procedure-related knee pain or swelling relative to hemathasia. Conclusion Based on results from Level 1 studies, intra-articular injection of PRP improves pain and function in patients with knee osteoarthritis for up to 12 months and is superior to HA, regardless of leukocyte number or number of injections. Independent of the type and frequency of PRP injection, the results of this review point to the routine clinical use of intra-articular injections of PRP for knee osteoarthritis.
Source link: https://europepmc.org/article/MED/36173473
Introduction The new methods in hip osteoarthritis management include an articular injection of platelet-rich plasma and hyaluronic acid. In patients with hip OA, the aim of this research was to determine the safety of IA injections of PRP, HA, and their combination in patients with hip OA. HA and PRP are two IA steps that can be used in OA in the preoperative stages of disease. Patients with grade 2 and 3 hip OA were included in this analysis and then randomly divided into three injection groups: PRP, HA, and PRP+ HA. One hundred five patients were randomly accepted into HA, PRP, and PRP + HA groups. In comparison to the HA group, the observed increase in the PRP + HA and PRP groups showed significant differences in the WOMAC and Lequesne total scores and the activities of daily living subscale of Lequesne, in which the observed change in the PRP + PRP + PRP + PRP groups was significantly higher than the HA group. Although all three interventions were intended to pain relief and function in patients with hip OA, the therapeutic effects of PRP and PRP + HA injections lasted longer, and patients' health, disability, and ADL were superior to HA in the long run. Trial registration http://www. irct. ir/, a WHO Primary Register registration scheme, registered the study on 29/11/2019 with the registration number IRCT20130523013442N30.
Source link: https://europepmc.org/article/MED/36096771
OA and related studies on the use and safety of HA in the treatment of OA have been widely used. Therefore, the aim of this study was to investigate the subject specifics of harnessing HA for the treatment of OA, as well as analyze the key trends and hotspots by using a bibliometric approach. Methods: The articles published in the Web of Science Core Collection from 1 January 2002 to 31 December 2021 were accessed, and the relevant information of HA for the treatment of OA was extracted after screening. United States was the most innovative nation with total 689 publications, while League of European Research Universities Leru was the top institution with total 126 publicatios. At present, there are already mixed opinions on the efficacy of HA for the treatment of OA.
Source link: https://europepmc.org/article/MED/36185454
Patients with KOA were admitted to the Affiliated People's Hospital of Ningbo University and Taizhou Orthopaedic Hospital from 2018-11 to 2021-11, according to Methods. 126 patients with KOA were admitted to the Affiliated People's Hospital of Ningbo University and Taizhou Orthopaedic Hospital from 2018-11 to 2021-11 were enrolled from 2018-11 to 2021-11. In group A, three months after diagnosis, knee joint pain and function, inflammatory cytokine levels, and oxidative stress indicators were greater than those in group B. After arthroscopic joint debridement in treating KOA, the combination of platelet-rich plasma and hyaluronic acid can have dramatic effects, reduce knee pain, accelerate knee joint function, reduce inflammation, reduce joint pain, and reduce oxidative stress, as well as reduce oxidative stress and raises.
Source link: https://europepmc.org/article/MED/36128500
Background: Osteoarthritis of the knee is one of the most common disorders worldwide, and pain management of this disease is crucial. Both male and active adults were diagnosed with osteoarthritis of the knee by MRI and active adults, and 60 participants were registered in the RCT. Results: Comparing statistically significant differences between groups, VAS scores were significant at post-test measurement at 24 h, at 15 days and 1 month. In the short term, pain intensity in knee osteoarthritis treatment in patients undergoing DN and conventional US+ isometric therapy has decreased, but the HA group shows an increase in pain intensity in long-term. knee function improvement at various stages of the study's various intervention groups shows a significant difference. The best option for osteoarthritis treatment is a blending of DN and HA in clinical practice.
Source link: https://europepmc.org/article/MED/36078628
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