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Various organizations have investigated the effects of hydrogel parameters in vitro and in vivo on desired material performance characteristics. Two variables at a time. We used thiol-ene click chemistry with a crosslinker to produce a method that minimizes material quality shifts and allowed several material characteristics to be independently verified a single variable at a time, allowing multiple material properties to be independently maintained constant to monitor a single parameter at a time. Customizing the concentration of crosslinker to obtain an almost constant stiffness for various HA hydrogel molecular weights and polymer concentrations was achieved. To minimize confounding variables in experimental hydrogel designs, the test that was developed to obtain independent control of hydrogel parameters may be used by others for other hydrogel polymers, cell sizes, or cell culture medium compositions.
Source link: https://europepmc.org/article/MED/36044886
Background: The new treatments in hip osteoarthritis management consisting of an intraarticular injection of platelet-rich plasma and hyaluronic acid. In patients with hip OA, this research was designed to determine the safety of IA injections of PRP, HA, and their mixture. HA and PRP are two IA steps that can be used in OA in the preoperative stages. Patients with grade 2 and 3 hip OA were included in this research and were randomly divided into three injection groups: PRP, HA, and PRP + HA. In comparison to the HA group, the observed change in the PRP + HA and PRP groups showed significant variations in the WOMAC and Lequesne total scores and the daily living subscale of Lequesne, which in the 6th month was substantial higher in the PRP + PRP + PRP and PRP groups, demonstrating significant differences regarding the HA and PRP groups. Conclusion: Although all three interventions were associated with pain reduction and functionality in patients with hip OA, PRP + HA injections lasted longer, and patient satisfaction, mobility, and ADL were all superior to HA in the long run, especially as the results of these two interventions on patients' health and stability were similar to HA in the long run. In addition, the addition of HA to PRP was not associated with a significant rise in the therapeutic results. Trial registration is required on 29/11/2019, according to the study, the registry of Clinical Trials web http://www. irct. ir/, a WHO Primary Register site, with the registration number IRCT20130523013442N30.
Source link: https://europepmc.org/article/MED/36096771
Background The lips and perioral region play a vital role in facial aesthetics. This may explain why the lips and perioral area are often requested focus areas for aesthetic treatments that preserve the client's natural features. Aims To assess the safety and effectiveness of the rejuvenation of the perioral area with an injectable product containing high-molecular-weight native hyaluronic acid and a group of amino acids. Patients/methods 37 female patients underwent three monthly sessions of intradermal injections of HMW HA gel with a cluster of AAs, according to this open-label observational study. Patients' responses were mixed throughout the investigation. All patients showed improvement in the perioral region, according to the subjective reports conducted by patients and by the investigator during follow-up and at the end of the study. HMW HA gel and AA injections to the perioral region resurfaces, and it's safe and effective.
Source link: https://europepmc.org/article/MED/36074513
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