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In vitro, a granular hydrogel of sodium hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation as well as axonal extension, suggesting that the hydrogel can mimic an extracellular matrix structure to promote neural regeneration. We transplanted a hyaluronic acid granular hydrogel nerve guidance conduit in this report to fill a 10-mm sciatic nerve scare gap in this paper. These findings indicate that tissue-engineered nerve conduits containing hyaluronic acid granular hydrogels efficiently aid in the healing of the injured sciatic nerve's damaged sciatic nerve's morphological and functional recovery. The nerve conduits can be used as a scaffolding device for peripheral nerve injury repair.
Source link: https://europepmc.org/article/MED/36018191
About 80% of breast cancer-related deaths are due to metastasis to distant organs. This is partially due to the lack of experimental methods to study metastatic site-specific interactions, particularly in the context of brain metastatic breast cancer. By striking a balance between proliferating and dead cells, HA hydrogel induced a near-dom dormant state in spheroids. In HA hydrogels, the ratio of %p-ERK to %p-p38 positive cells is significantly lower than that of suspension cultures. Further, it has been reported that the hydrogel-induced mass dormant state is reversible.
Source link: https://europepmc.org/article/MED/36354182
Patients often suffer with more severe health issues as a result of bacterial infections related with wound healing. Moreover, dopamine additions to the hydrogel gives the wound dressing with increased adherence, aideing in wound healing. The HAMA-TPP-DMA hydrogel, according to the latest results of in vitro and mice wound models in vivo, can effectively fight bacteria and promote wound healing in mice. Hence, this hydrogel dressing with superior antibacterial infection and wound healing capabilities is a promising wound repair option.
Source link: https://europepmc.org/article/MED/36321788
Hydrogel tissue adhesives that are currently available are often produced by mixing two or two polymeric components. The development of the first single-component hyaluronic acid hydrogel adhesive based on phenylboronic acid-diol ester linkages is the subject of this study. Phenylboronic acid not only acts as a cross-linker to produce hydrogel, but it also acts as an adhesion site for glycosyl compounds present in biological cell membranes. The hydrogel had significantly higher adhesion strength than commercial fibrin glue, according to Adhesion experiments.
Source link: https://europepmc.org/article/MED/IND607873767
The hydrogel membrane impregnated with temoporfin had a fixation index of > 89%, according to the study. HM-T15 and HM-T30 had excellent antibacterial activity, according to the inhibitory activity of temoporfin. The cell survival rate of HM-T15 was 73% higher than that of the control group, indicating that temoporfin exposure for 15 min did not have cytotoxic effects on L-929 cells. After 14 days of dark incubation, HM and HM-T15 hydrogel membrane membranes demonstrated good cell adhesion and proliferation. However, pro-inflammatory gene expression was reduced by a temoporfin-containing hydrogel membrane.
Source link: https://europepmc.org/article/MED/36365133
In addition, stem cell therapy has made it possible to repair and regenerate IVD tissue, among which adipose-derived mesenchymal stem cells transplantation therapy has become a hot topic of current research. Consequently, this trial was designed to explore the safety and effectiveness of using autologous cultured ADMSCs with hyaluronic acid hydrogel in the treatment of DLBP. Methods and analysis This is a randomised, dose-escalation, placebo-controlled, double-blind, single-centre, phase II clinical trial based on randomization, dose-escalation, placebo-controlled, double-blind, single-centre research to determine the effectiveness and safety of autologous cultured ADMSCs mixed with HA hydrogel in the treatment of patients with DLBP. After 3 weeks, all patients will need liposuction to obtain ADMSCs, followed by autologous cultured ADMSC mixtures or placebo transplantation. Ethics and dissemination The study protocol has been approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University and registered in the Chinese Clinical Trial Registry, according to the Chinese Clinical Trial Registry.
Source link: https://europepmc.org/article/MED/36283750
By systematically increasing the HA concentration and the streaming electrolyte pH and ionic strength, the streaming potentials of hyaluronic acid hydrogel films are measured and theoretically evaluated. For example, the HA surface potentials are only 0 mmol L -1, where u03c8 D /2 u2248-8 mV is the Donnan potential, less than the u03c6-potentials provided by the Helmholtz-Smoluchowski interpretation, which is significantly lower than the u03c8 D /2 u2248-8 mv, where u03c8 D /2 mV, which is the tz-tz-u03c8 D u03c8 D u03c8 D u03c8 D u2248 -8 mV, the Donnan potential, u03c8 D u03b6-potentials provided by the u03b6-tz-e omol L u03c8 D mmol L u2348 -8 ionic strength of -8 mV, u03c8 D u03c8 D Our review provides formulas for the HA concentration S and hydrodynamic permeability l2, which are specifically defined as simple power-law functions of the as-prepared HA concentration c ha, consistent with independent assessments of the HA solution permeability and polyelectrolyte-hydrogel swelling theory.
Source link: https://europepmc.org/article/MED/36279307
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