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Acid Hyaluronic Hydrogel - Crossref

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Last Updated: 16 November 2022

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O054 A novel hyaluronic acid hydrogel as an extracellular matrix to improve adipose tissue graft survival in autologous transfer for breast cancer reconstruction

Abstract Introduction Adipose tissue transfer is used for correcting breast contour defects after cancer surgery. Primary murine adipocytes mixed with HA gel were subcutaneously injected into a murine adipocyte mix mixed with HA gel, with survival and gene expression determined. In 4u20135 days, tissue hyaluronidases can degrade the novel HA hydrogel. When compared to the control group, Mature adipocyte gene expression indicators showed no difference. In vivo, primary murine adipocytes injected in vivo showed no difference in survival at higher gel volumes relative to controls. Conclusion The novel engineered HA hydrogel has excellent chemical stability for injection and can promote adipocyte survival in vitro and in vivo, and is ready for a pilot human trial. About the Take-home message Our latest HA gel can be used in vivo and in vitro, and it provides a potential method for increasing adipocyte transplantation.

Source link: https://doi.org/10.1093/bjs/znac242.054


Hydrogel composed of type II collagen, chondroitin sulfate and hyaluronic acid for cartilage tissue engineering

paraphrasedoutput:BACKGROUND: Cartilage tissue engineering is a promising way to fix cartilage defects. OBJECTIVE: This study was designed to produce cartilage hydrogel from type II collagen, chondroitin sulfate, and hyaluronic acid to determine their gelation property and compressive strength, as well as analyze the possibility of using cartilage tissue engineering. Umbilical cord stem cells were co-cultured with hydrogel scaffolds to determine its cytotoxicity and cellular presence during co-culture, and determine whether stem cells had cellular activity during co-culture; histological staining was used to test the hydrogel loaded with stem cells. The results of umbilical cord stem cell co-culture revealed that the hydrogel had good cytocompatibility, and stem cells had strong activity in the hydrogel. A versatile living environment for umbilical cord stem cells, so that they maintain normal cell morphology and activity, could be a good application area for cartilage tissue engineering.

Source link: https://doi.org/10.3233/bme-221404


Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism

Overall, cosmetic repair techniques tend to short-term pain relief; however, hyaline cartilage regeneration remains elusive, leaving both the repair tissue and surrounding healthy tissue vulnerable to long-term wear. The aim of this research was to develop and test a cartilage-penetrating hyaluronic-acid hydrogel to repair cartilage biomechanics and prevent tissue degeneration. After simulation degeneration of explants, the HA-based hydrogel delivered a 48. 5% rise in compressive modulus and a decrease in permeability at time zero. detrimental changes to compressive modulus and permeability observed in non-treated explants were mitigated by degenerative culture model hydrogel application prior to or midway through the process. In addition, localized proteoglycan was observed in degenerative culture conditions alone, but hydrogel therapy greatly increased matrix retention. Lastly, NITEGE staining and gene expression analysis revealed that the HA gel had the ability to reduce chondrocyte catabolic activity.

Source link: https://doi.org/10.1101/2022.05.17.492335


Effects of Temoporfin-Based Photodynamic Therapy on the In Vitro Antibacterial Activity and Biocompatibility of Gelatin-Hyaluronic Acid Cross-Linked Hydrogel Membranes

The results revealed that the hydrogel membrane impregnated with temoporfin had a fixation percentage of > 89%. HM-T15 and HM-T30 demonstrated remarkable antibacterial activity, according to the inhibitory activity of temoporfin. Cell survival rate of HM-T15 was 73% higher than that of the control group, suggesting that temoporfin exposure for 15 min did not have cytotoxic effects on L-929 cells. After 14 days of dark incubation, both HM and HM-T15 hydrogel membrane membranes demonstrated excellent cell adhesion and proliferation. This report demonstrated the promise of temoporfin for innovative biomaterials and delivery systems applied to new regenerative periodontal therapies.

Source link: https://doi.org/10.3390/pharmaceutics14112314


Injection laryngoplasty of human adipose-derived stem cell spheroids with hyaluronic acid-based hydrogel improves the morphological and functional characteristics of geriatric larynx

SHAM, injected with PBS; GEL; injected with HA-CA hydrogel; and MONO, injected with single hASCs in HA-CA hydrogel; and SP, injected with HA-CA hydrogel in HA-CA hydrogel; and SP, injected with hASC spheroids in HA-CA hydrogel; and SP, injected with HA-CA hydrogel; and SP, injected with hASCs Results In the SP group, the total myofiber cross-sectional area and myofiber number/density were significantly higher than in the other groups. The glottal gap area in the SP group was significantly reduced in comparison to other groups in functional analysis. The phase difference in the vocal fold during vibration was smaller in the SP group than in the other groups, but not statistical significance, so the difference did not reach statistical significance. Conclusions Injection of hASC spheroids with hyaluronic acid-based hydrogel enhances the morphological and functional characteristics of geriatric larynx.

Source link: https://doi.org/10.1186/s40824-022-00261-x

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions