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The filamentous Ascomycete fungus Aspergillus n. . . . 's high-yield citric acid production requires a complex of extreme dietary conditions, of which maintaining a low manganese ion concentration is a key feature. Citric acid production mainly uses stainless-steel tank fermenters, but glass bioreactors used for strain reduction and manufacturing process development also contain stainless steel components, in which manganese is a key alloying component. Manganese ions were leaching from the bioreactor into the growth media, resulting in altered fungal physiology and morphology, as well as a dramatic decrease in citric acid yields, as shown here. Citric acid yield decreased due to early cultivation's high amounts of manganese ions during early cultivation. However, the effect of manganese ions on the reduction of citric acid yield in the second half of fermentation diminished.
Source link: https://doi.org/10.3389/fbioe.2022.935902
Abstract In higher eukaryotic organisms, the mitochondrial citrate transport protein functions as a malate transport protein, catalyzing the exchange of citrate plus a proton for malate between mitochondrial and cytosol across the inner mitochondrial membrane. These results show that the CTPA plays an effect on growth and thus citric acid metabolism of A. n. . . . changes, particularly in the early-log phase, but not the citric acid-producing period. in A. n. . . . , this is the first study to show that ctpA disruption leads to changes in phenotypes as a result of citric acid production.
Source link: https://doi.org/10.1080/09168451.2016.1164583
The phenotype of the cocA disruptant differed in part from strain WU-2223L's after culture for 12 days under CA production conditions, and it was less than that produced by strain WU-2223L. This study is the first to show that cocA and its protein product directly contribute to substantial CA production by A. n. . . . , and it provides important insight into fermentation microbial organic acid production.
Source link: https://doi.org/10.1080/09168451.2019.1574205
With NADP+ as a cofactor, a cofactor in the tricarboxylic acid cycle catalyzes oxidative decarboxylation of isocitic acid to produce u03b1-ketoglutaric acid. The amounts of citric acid produced and consumed by OPI-1 during the 12-d cultivation period decreased by 18. 7 and 10. 5%, respectively, as well as those by WU-2223L. These results show that the amount of citric acid produced by A. n. . . . can be modified with the NADP+-ICDH activity.
Source link: https://doi.org/10.1080/09168451.2014.918483
Citric acid production using agro-waste as a cheap carbon source aids in waste disposal and cost reduction in production. MATH EQ 2 u00b0C. The effect of corncob concentrations of 5 % w/v on citric acid production was investigated. The concentration with the highest yield of citric acid was optimized using copper ions concentrations of 0 to 0. 4 g/l. After 8 d of fermentation, the supplemented corncob medium had the highest citric acid production and fungal biomass. According to studies on corncob concentrations, 25 percentw/v of corncobs had the highest citric acid production and fungal biomass. Corncob was found to be a good substrate for citric acid production by A. n. . . . , and an addition of copper ions at lower concentration can help to improve citric acid production.
Source link: https://doi.org/10.9734/jamb/2022/v22i830477
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