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The host's immune response during T. cruzi infection is critical for fighting parasitism, which is essential for survival. We examined the relationship of host cyclooxygenase to the behaviour of EVs shed by T. cruzi strain Y in infected macrophages in this research. Comparing to the controls, RAW 264. 7 macrophages exposed to EVs-Y and then infected with trypomastigote-based T. cruzi had less NO, and an increased number of trypomastigote forms were internalized in the cell, indicating that the parasite's effects were stronger in the cell than controls, suggesting that the parasite's vivacious properties favor the parasite. These findings indicate that EVs-Y modulates the macrophage response in favour of T. cruzi and point to a role for COX in the effects of EVs.
Source link: https://europepmc.org/article/MED/36332896
After a subpoena blob forming glaucoma surgery, inflammation-driven scarring is a significant contributing factor to surgical failure. Mitomycin C, the current gold standard anti-scarring adjuvant drug, has variable effectiveness and is associated with significant risks. This research seeks to evaluate the effects of ASA and MMC in an in vitro model of subconservative scarring. TGFu03b21 plus or minus ASA, or MMC, were used in vitro with Glaucoma patient-derived Tenon's capsule fibroblasts. ASA greatly reduced the secrecy of the pro-inflammatory lipid mediators prostaglandin F1u03b1 and 6-keto-prostaglandin F1u03b1 and much improved undercoverion of the pro-resolving mediators 5-hydroxyeicosaenoic acid, 15-HETE, and 18-hydroxyeicosapentaenoic acid in cytokine-activated HTCFs, among a u03b1u03b1u03b1u23-pro-pro-pro-pro-pro-activated v1u03b1u03b1u03b1u3b1u03b1u03b1u03b1aenoeto hydroxye epuroiono1u03b1u03b1u03b1u03b1u03b1u03b1u03b1u03b1u03b1u03b1u03b The ASA's effects are correlated with a unique lipid mediator expression profile, indicating that ASA-induced inflammation-mediated scarring may be a promising tool to reduce inflammation-mediated scarring and could be a novel alternative to surgical adjuvants.
Source link: https://europepmc.org/article/MED/36273575
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