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Acetylsalicylic Acid - DOAJ

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Last Updated: 13 November 2022

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Does the continuation of low-dose acetylsalicylic acid during the perioperative period of thyroidectomy increase the risk of cervical haematoma? A 1-year experience of two Italian centers

paraphrasedoutput:Methods is a medical journal published in Italy. During the perioperative period of thyroidectomy in two high-volume thyroid surgery centers between January 2021 and December 2021, the primary aim of this research was to investigate the incidence of cervical haematoma in patients receiving low-dose acetylsalicylic acid, specifically ASA 100 mg/day. Patients were divided into two groups: those not taking ASA were included in Group A, while those receiving this drug in Group B were divided into two groups: those not receiving ASA were divided into two groups, while others receiving this drug in Group B were divided into two groups, while those receiving this medication in Group B were divided into two groups. Univariate analysis was conducted to compare these two groups. Moreover, multivariate analysis was employed to determine the use of low-dose ASA as an independent risk factor for cervical haematoma during the study period. In Group A, there were four cervical haematomas without requiring surgical revision of haemostasis, as well as four cervical haematomas with surgical repair of haemostasis, and four cervical haematomas necrequiring surgical revision of haematomas, as well as four cervical haematomas requiring surgical revision of haematomas. There was one cervical haematoma in Group B, necessitating surgical reconstruction of haemostasis.

Source link: https://doi.org/10.3389/fsurg.2022.1046561


Anti-viral activity of acetylsalicylic acid against human rhinovirus 14 infection involves suppression of VP3 expression and infection-dependent down-regulation of CD54

Human rhinoviruses have been shown to cause mild upper respiratory tract infections. Acetylsalicylic acid may be a drug with demonstrated anti-virus activity in vitro and in vivo. Flow cytometry determined human rhinovirus infection by flow cytometry using a monoclonal antibody against the major capsid protein HRV-VP3 in conjunction with analysis of surface expression of CD54, a key molecule involved in the initiation of an immune response. The HRV-VP3 protein is expressed in a single cell by in vitro studies by Our in vitro studies.

Source link: https://doi.org/10.1016/j.crviro.2022.100022


Acetylsalicylic Acid and Salicylic Acid Inhibit SARS-CoV-2 Replication in Precision-Cut Lung Slices

Since it could use similar pathways to influenza viruses, we wanted to see if ASA and its metabolite salicylic acid inhibit SARS-CoV-2. Although the chemicals did not interfere with viral entry, it did lead to reduced viral RNA expression after 24 h, indicating that post-entry pathways were blocked by the compounds.

Source link: https://doi.org/10.3390/vaccines10101619


Carbohydrate metabolism in diabetic rat’s heart – the effects of acetylsalicylic acid and heat preconditioning as HSP70 inducers

However, after being exposed to sub-total heat stress, the heart has the ability to produce heat shock proteins. HSP70 protein level, lower glycogen, glucose-6-phosphate content, glycogen phosphorylase and hexokinase activity, as well as elevated glucose levels and PFK activity have been found in cardiovascular, phosphate, and hexokinase activity in HP-diabetic hearts. An additional increase in HSP70, further reduction of glycogen, glucose-6-phosphate, glycogen phosphorylase, and hexokinase, as well as an increase in glucose and PFK in the heart was triggered by an ASA-pretreatment of HP-diabetic animals. The ASA, which was delivered prior to HP, is a potent HSP70 co-inducer and causes an additional rise in the HSP70 protein level in heart.

Source link: https://doi.org/10.2478/macvetrev-2022-0021

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions