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Acetyl cysteine - Springer Nature

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Last Updated: 13 November 2022

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Target-Based Virtual and Biochemical Screening Against HMG-CoA Reductase Reveals Allium sativum-Derived Organosulfur Compound N-Acetyl Cysteine as a Cardioprotective Agent

When compared to pravastatin, the initial in silico screening of organosulfur compounds showed that among all the tested compounds, N acetyl-cysteine, S -ethyl-cysteine, alliin, and S -allyl-cysteine were among the top commercially available modulators of HMG-R activity. 00b1 0. 51 g/m3/bcM, 1. 2 billion bcM, 7. 031 u00b1 0. 51 %u03b1 0. 51 % u00b1 0. 53 %u03b1 0. 51 u00b1 0. 01. 1 million 0. 51 u03b1>u03bcM, respectively, much higher than the IC_50 value of ascorbic acid 0. 1, which was much higher than the b1 ty 0. 6 u03b1 0. 05 1. 01 %u00b1 u03b1 1. 01 1. 01 6. 01 1. 03 u03b1 0. 51 0. 61 0b1 0. 52 u03b1 0. 52 0. 05 00b1 0. 05 0 b1 u03b1 0 1. 2 u03b1 1. 1 0b1 0. 051 IC_50 value of ascorbic acid 00b1 1. 20u03b1 0 b1 tylc In addition, our enzyme kinetics results showed that N acetylcysteine shows significant inhibition against in vitro -u03b2-hydroxy-CoA reductase production. N acetylcysteine, according to our in vitro and vivo research, has notable antioxidant properties and competitively inhibits enzymatic activity of u03b2-methyl-glutaryl-CoA, which we demonstrate among other related organosulfur compounds.

Source link: https://doi.org/10.1007/s43450-022-00330-1

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* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions