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Acetyl Coenzyme - Europe PMC

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Last Updated: 13 November 2022

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Functional characterization of two homologs of yeast acetyl-coenzyme A synthetase in the entomopathogenic fungus Beauveria bassiana.

Acetyl-coenzyme A synthetase converts acetate and CoA into acetyl-CoA, linking cell metabolism and physiology. Two Acs proteins were functionally identified in the filamentous insect pathogenic fungus Beauveria bassiana, which was described in this study. BbAcs1 aids in vegetative growth on fatty acids as a carbon source, but BbAcs2 did not. Acs2 played a more prominent role than Acs1 in B. bassiana, where it links acetyl-CoA metabolism to the lifestyle of entomopathogenic fungi.

Source link: https://europepmc.org/article/MED/36175799


Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

Proliferating cells are dependent on acetyl-CoA to promote membrane biogenesis and acetylation. As nutrient availability changes, several organelle-specific pathways are available for supply of acetyl-CoA, and knowing how cells maintain acetyl-CoA balance under such strains is crucial. Multiple cell lines knocked out on several cell lines, which decreased fatty acid production and increased reliance on extracellular lipids or acetate. Peroxisomal oxidation of exogenous lipids as a primary source of acetyl-CoA for lipogenesis and histone acetylation, according to metabolic tracing and PEX5 knockout studies, highlighting the importance of inter-organelle crosstalk in aiding cell survival in response to nutrient fluctuations.

Source link: https://europepmc.org/article/PPR/PPR550278


Correlation of acetyl-coenzyme A carboxylase 1 with Th17 and Th1 cells, serving as a potential prognostic biomarker for acute ischemic stroke patients.

Hence, this research was designed to investigate the connections between blood ACC1, Th17, and Th1 cells, as well as ACC1's potency as a prognostic biomarker for AIS management. Methods ACC1 in peripheral blood mononuclear cells of 160 AIS patients and 30 controls were determined by RT-qPCR; blood Th17 and Th1 cells in AIS patients were determined by flow cytometry. AIS patients' incidences were up in AIS patients compared to controls, which indicated a good risk of AIS in the region under the curve of 0. 872. In addition, ACC1 was positively associated with Th17 and Th1 cells in AIS patients. In addition, ACC1, Th17, and Th1 cells were positively linked to the National Institutes of Health Stroke Scale score in AIS patients. The ACC1 high vs. low and Th17 high vs. low were both connected to short recurrence-free survival in AIS patients, and Th1 cells were not correlated with RFS.

Source link: https://europepmc.org/article/MED/36059084


Characterization of mutations conferring inherent resistance to acetyl coenzyme A carboxylaseÔÇÉinhibiting herbicides in turfgrass and grassy weeds

An herbicide-resistant weed control device that uses naturally occurring mutations of acetyl-1u2010coenzyme A carboxylase u2010inhibiting herbicides may be able to provide herbicide selectivity and turf control. Merr. The Agrostis capillaris L. , Festuca ovina L. , Festuca rubra L. , Lolium multiflorum Lam. , Paspalum dilatum Poir, Poa annua L. , Zoysia japonica Steud. , and Z. matrella are among the ten species listed in Agrotum dilatum Poir. In only three of the 24 species tested, three site of action point mutations giving rise to ACCase herbicides were discovered at a position 1781 in only three of three of the 24 species examined.

Source link: https://europepmc.org/article/MED/IND607867550

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions