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Acetyl Coenzyme - DOAJ

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Last Updated: 13 November 2022

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Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant

N-acetyl transferase 1 is a xenobiotic metabolizing enzyme that uses acetyl coenzyme A as a cofactor for N-acetylation of many carcinogens, including aromatic amines and alkylanilines. AcCoA kinetic parameters for N-acetyltransferase activity measurements against p-aminobenzoic acid, 4-aminobiphenyl, benzidine, and 3,4-dimethylaniline were measured in the current study, using Chinese hamster ovary cells stably transfected with human NAT1*4 or NAT1*14B.

Source link: https://doi.org/10.3389/fphar.2022.931323


Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells

Using the IVIS luciferase imaging system, lung metastasis mouse models were used to determine the effect of calcium/calmodulinu2010dependent protein kinase 2 or ATP citrate lyase inhibitors on lung metastasis. Result We discovered autophagy in KL cancer cells increased acetylu2010coenzyme A, which helped with the acetylation and stabilization of the EMT-inducing transcription factor Snail. The autophagy/acetyl/acetyl/u2010Snail axis' autophagy/acetyl/u2010Snail axis was further demonstrated in tumor tissues and in autophagy-activated pancreatic cancer cells. In a mammalian target of a rapamycin complex 1 u2010independent manner, TFEB acetylation in KL cancer cells sustained pro-u2010metastatic autophagy in a pro-u2010metastatic autophagy. Conclusions This research reveals that autophagy produced by autophagy increases Snail acetylation, which then promotes migration and metastasis of KRASu2010LKB1 co-u2010mutated lung cancer cells, as well as the inhibition of autophagy/acetylu2010CoA's use of CAMKK2 or ACLY inhibitors may be a potential therapeutic approach to minimize metastasis of KL lung cancer cells.

Source link: https://doi.org/10.1002/cac2.12332

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions