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After an overnight fast during an euglycemic insulin-glucose clamp, six IDDM patients and six normal subjects were treated to a saline infusion for 2 h, an acetoacetic acid infusion for another 2 h, and then a saline infusion. After an overnight fast during an euglycemic insulin-glucose clamp, six IDDM patients and six normal subjects were given saline, lactic acid, and saline infusions at the same rates of infusion. In comparison to baseline values in healthy subjects and in a 14. 7 and 7. 6% rise in RPF, respectively, in IDDM subjects, respectively. The initial acetic acid infusion was raised from 0. 1 mM to 0. 3 mM, which was consistent with negligible changes in ketone body and lactic acid concentrations, following the same regimen as the previous organic acid infusion. Both lactic and lactic acid tubular reabsorption rates were three to five times higher during acetoacetic acid and lactic acid infusion, respectively, during saline infusion. In conclusion, lactic acid and acetoacetic acid infusion resulting in circulating patterns of these intermediate metabolites similar to those often observed in poorly controlled IDDM subjects resulting in a significant rise in GFR and RPF in both normal and IDDM patients.
Source link: https://doi.org/10.2337/diab.36.9.1073
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