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Acetaminophen Toxicity - DOAJ

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Last Updated: 15 February 2022

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Effects of Ozone and L-Carnitine on Kidney MDA, GSH, and GSHPx Levels in Acetaminophen Toxicity

This research was designed to determine the therapeutic effects of medical ozone and L-carnitine therapy on acetaminophen-induced kidney injury by measuring malondialdehyde, glutathione, and GSHPx values. 56 rats were randomly divided into 8 groups with 7 rats in each group in this study, with 7 rats in each group. In the kidney tissues only in the “APAP + Ozone” and “APAP + L-carnitine” groups, relative to the control groups. In addition, the decrease in the GSH and GSHPx levels of the kidney tissue in the study groups' "APAP + Ozone + L-carnitine" and "APAP + Ozone + L-carnitine" groups were significant compared to the control groups, and the largest decreases were observed in the "APAP+ Ozone" and "APAP + Ozone + L-carnitine" groups.

Source link: https://doi.org/10.9775/kvfd.2019.22456


Management of acetaminophen toxicity, a review

Acetaminophen is a commonly used drug in our environment with no adverse effects, and it has little adverse effects. The APAP dose-intake was excessive, despite this, several patients affected by APAP hepatotoxicity were not aware that the APAP dose-intake was excessive. The drug's ingested doses, as well as the length of time from APAP ingestion to N-acetylcysteine therapy, are the most significant determining factors in both the development and severity of APAP hepatotoxicity. The ingestion of a toxic dose of APAP can result in various clinical signs that depend heavily on the time elapsed since the intake. After an acute single overdose, the Rumack-Matthew nomogram is safe, with the “possible hepatic toxicity” point 200 g/mL at 4 hours and 25 g/mL at 16 hours. NAC is the antidote to APAP intoxication, and it can be administered or intravenous.

Source link: https://doi.org/10.5281/zenodo.3470262

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions