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Acetaminophen Liver - Europe PMC

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Last Updated: 15 November 2022

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Schisandra chinensis essential oil attenuates acetaminophen-induced liver injury through alleviating oxidative stress and activating autophagy.

Context Schisandra chinensis Baill of Context Schisandra chinensis Baill. Symbols are found in essential oil compositions that are thought to have anti-inflammatory properties in the liver. In mice, this paper investigates the role of SCEO in the treatment of acetaminophen-induced liver injury. C57BL/6 mice were randomly divided into seven groups: normal; APAP plus bicyclol; APAP plus bicyclol; APAP plus SCEO; APAP plus SCEO; APAP plus bicyclol; APAP plus bicyclol; APAP plus SCEO; APAP plus; APAP plus bicyclol; APAP plus bicyclol; APAP Plus SCEO; APAP Plus SCEO; ; APAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAPAP; APAPAPAPAPAPAPAPAPAPAPAPAPAPAP; APAP; ; AP; and AP; and AP; ; AP; APAPAP; AP; APAP; ; AP; and AP; ; AP; ; AP; and AP; ; and AP; ; Results Compared to APAP overdose, SCEO pre-treatment reduced the serum levels of AST, ALT, TNF-u03b1, and IL-6 in comparison to APAP's overdose. In addition, porcine matrices from our study showed that SCEO pre-treatment reduced liver injury caused by oxidative stress by raising Nrf2, HO-1, and GCL. In APAP overdose mice, SCEO stimulated autophagy, which reduced hepatic LC3-III and reduced p62. In vivo, SCEO shields hepatocytes from APAP-induced liver injury, providing a solid theoretical basis for the development of novel therapeutics.

Source link: https://europepmc.org/article/MED/35588406


Aging aggravates acetaminophen-induced acute liver injury and inflammation though inordinate C/EBPα-BMP9 crosstalk

Background: Bone morphogenetic protein 9 is almost exclusively produced in the liver and reaches tissues throughout the body as a mystery protein in research. However, the role and mechanism of BMP9 in aging-associated liver injury and inflammation are still unclear. Increased expression of CCAAT/enhancer binding proteins, u03b1 and BMP9 was found in aged livers, as well as in hepatocytes and macrophages isolated from the aged mice. The new findings showed that excess BMP9 is directly related to APAP-induced hepatocyte injury and death, evidenced by stimulated drosophila mothers against decapengraftidase, elevated beta-related beta-u2010galactosidase, and a greater senescence phenotype in the UG20 region. Conclusions: In summary, the present study identifies the crucial roles for the C/EBP-BMP9 crosstalk and provides insight into the relationship between hepatocytes and Mu03a6s during acute liver injury.

Source link: https://europepmc.org/article/PPR/PPR570489


Targeting PARK7 Improves Acetaminophen-Induced Acute Liver Injury by Orchestrating Mitochondrial Quality Control and Metabolic Reprogramming.

Mitochondrial dysfunction and oxidative stress have been cited as key events in acute liver injury by acetaminophen. PARK7, a mitochondrial stress protein, is a gene that regulates mitochondrial quality control in APAP-induced hepatotoxicity. In this research, L02 cells, AML12 cells, and C57/BL6 mice were all used to create models of APAP-induced acute liver injury in this study. Following APAP treatment, changes in cell viability, apoptosis, reactive oxygen species level, serum enzyme production, and pathological characteristics were evaluated. The results revealed that APAP treatment reduced cell viability and increased the apoptosis rate, ROS levels, serum enzyme activity, pathological damage, and PARK7 expression. These findings, taken together, indicate that PARK7 is involved in APAP-induced acute liver injury by regulating mitochondrial quality control and metabolic reprogramming. PARK7 may be a promising therapeutic target for APAP-induced liver injury, according to this.

Source link: https://europepmc.org/article/MED/36358500

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions