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Acetaminophen Ibuprofen - Europe PMC

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Last Updated: 06 November 2022

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What is the association between common medications (indomethacin, ibuprofen and acetaminophen) and spontaneous intestinal perforations in premature infants? A systematic review protocol

: Spontaneous intestinal perforation affects very low birth weight preterm neonates and accounts for 44% of gastrointestinal perforation. Despite being separate entities, the bulk of the data shows that SIP and those affected by necrotizing enterocolitis. This systematic review aims to find an association between common medications and SIP in the premature infant cohort, independently from NEC. Methods: Our research will investigate infants who have been exposed to either indomethacin, ibuprofen, or acetaminophen, where SIP is a reported outcome. The Cochrane Central Register of Controlled Trials, a health science librarian, will search Medline and Medline in Process using OVID, Embase Classic + Embase via OVID, the LILACS database, the LILACS database, and the Cochrane Library. Using the odds ratio, the comparative incidence of SIP by treatment group will be determined.

Source link: https://europepmc.org/article/PPR/PPR567257


Preclinical comparison of antinociceptive effects between ibuprofen, diclofenac, naproxen, and acetaminophen on acid-stimulated body stretching and acid-depressed feeding behaviors in rats.

Pain is a significant issue that affects societies' health and well-being. Nonsteroidal anti-inflammatory drugs are over-the-counter drugs that are often used for mild to moderate pain conditions. In an inflammation pain rat model, we investigated differences in therapeutic efficacies among the most commonly prescribed NSAIDs and acetaminophen. Following intraperitoneal administration of lactic acid, body stretching and food intake patterns were investigated. In adult male rats in both behavioral models, different lactic acid concentrations were first determined. Food restriction for 1-24 h before feeding experiments was identified at first, and 24 h were chosen for further tests in the feeding study. Also, acetaminophen, diclofenac, and ibuprofen raised food intake after 3. 2 percent lactic acid. In both stretching and feeding practices, there were no significant differences between various test drug efficacies.

Source link: https://europepmc.org/article/MED/36256732


Dual medication therapy (acetaminophen and ibuprofen) for the management of patent ductus arteriosus in preterm infants: a systematic review and meta-analysis.

Aims : To determine the safety of dual medication therapy vs. single medication therapy in medical diagnosis of PDA in premature infants, it was investigated. Following the first treatment course between DMT and SMT, there were no differences in the rates of successful PDA closure, but there were no significant differences in secondary outcomes and adverse events such as PDA ligation, bronchopulmonary dysplasia, and necrotizing enterocolitis, etc.

Source link: https://europepmc.org/article/MED/36008521

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions