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Accelerated Biological Aging - Europe PMC

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Last Updated: 28 January 2022

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Physical and biological implications of accelerated aging on stereolithographic additive-manufactured zirconia for dental implant abutment.

This report was designed to primarily investigate the effects of accelerated aging on zirconia manufactured by digital light processing and conventional subtractive manufacturing of similar composition. Both the DLP- and SM-fabricated zirconia samples were grouped by age grouping, comprising 0 h, 5 h, and 10 h, respectively. Phase assemblage and surface topography of zirconia produced by different technologies were tested before and after aging. confocal laser scanning microscopy respectively investigated the biological effects of zirconia on human gingival fibroblast cell functions, including cell viability, proliferation, morphology, and adhesion, were also measured by live/dead viability assay, cck-8 assay, scanning electron microscopy, and confocal laser scanning microscopy. The DLP-fabricated zirconia demonstrated a higher initial cubic phase content and rate of phase transition than the SM-fabricated zirconia.

Source link: https://europepmc.org/article/MED/34924492


Accelerated biological aging in people with Down syndrome with full and segmental trisomy 21 begins in childhood as revealed by immunoglobulin G glycosylation

Cells from people with Down syndrome exhibit faster DNA damage and epigenetic aging signs. We carried out IgG glycan profiling of n=246 people with DS from three European countries and compared these to age-, sex-, and demography-matched general populations. We found that the IgG glycosylation ageing signs in DS were elevated. Age in people with DS corresponded to levels found in 19 years older euploids. IgG glycans without galactose and those with two galactoses as a result of a ratio of age in people with two galactoses and those with two galactoses is a factor of aging. Any aging marks were present in children with DS or older children with DS. IgG glycan profiles of a child with segmental duplication of only 31 genes on chromosome 21 were similar to those of age-matched DS children, which were outside the typical range of a child. This is the first non-epigenetic evidence of accelerated systemic biological aging in DS, which suggests it starts early in childhood.

Source link: https://europepmc.org/article/PPR/PPR432686


Accelerated Biological Aging Secondary to Cardiometabolic Risk Factors Is a Predictor of Cardiovascular Mortality: A Systematic Review and Meta-analysis.

Background Chronological age is one of the key risk factors of cardiovascular disease; however, the effect of biological ageing on CVD and outcomes is uncertain. The shortest LTL was associated with a 39 percent higher risk of MI and LTL in a multivariate-adjusted model. In the shortest tertile of LTL, we found a 28 percent higher risk of CV death after adjusting for chronological age and traditional covariance. Diabetes mellitus was associated with an increased risk of LTL attrition by 46%, according to the analysis of the studies that looked at the correlation between CV risk factors and LTL. Conclusions: LTL, a measure of biological age, has a strong relationship with MI and CV death, according to this report.

Source link: https://europepmc.org/article/MED/34822967

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions