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This is a rare and clinically complicated subtype of Crouzon syndrome with acanthosis nigricans. This multicenter research was conducted at three craniofacial hospitals in order to determine clinical outcomes in connection with the recommended interventions and treatment regimen for patients with CANs. CONCLUSIONS The study shows that patients with the mutation c. 1172C > A in the FGFR3 gene have a severe disease course, necrequiring multiple surgical interventions. It was not possible to distinguish the effect of a more acute clinical presentation from the effects of the treatment order on outcome.
Source link: https://doi.org/10.3171/2021.2.peds20933
A decrease in the number of insulin receptors in patients with extreme insulin resistance and acanthosis nigricans has been found on newly isolated monocytes and cultured fibroblasts compatible with a primary or genetic decrease in cell-surface insulin receptors. The fibroblasts of the acanthotic subject's fibroblasts internalized more insulin per available receptor in the presence of chloroquine, causing an elevated rate of insulin internalization. When the rate of insulin internalization was more specifically determined by determining the presence of acid-resistant, cell-associated radioactivity at 37 u00b0C, a similar increase in insulin internalization rate was apparent. Hence, a primary or genetic reduction of insulin receptors on cultured fibroblasts from a patient with acanthosis nigricans and insulin resistance is related to functional impairment of the remaining receptors, resulting in significant shifts in ligand processing and subsequent insulin therapy.
Source link: https://doi.org/10.2337/diab.35.2.148
A reduced number of insulin receptors has been attributed to a decreased number of insulin receptors, which is often associated with acanthosis nigricans and menstrual irregularities. Four affected females from one family, a mother, and three girls who appear to have the condition A syndrome appear to have the type A syndrome. We now have four impacted females from one family, a father, and three daughters who appear to have the condition A syndrome. In the affected twins, insulin dose-response studies to measure glucose metabolism and insulin sensitivity were conducted. With a decrease in maximal response, the dose response to insulin was shifted to the right.
Source link: https://doi.org/10.2337/diab.35.1.33
Both patients with severe target cell resistance to insulin are commonly found in patients with insulin resistance in both type A and B syndromes. Patients with acanthosis nigricans were clearly more hyperinsulinemic when compared to hyperandrogenized women of a similar body weight. Insulin binding to monocytes and red cells in patients with acanthosis was reduced in patients with acanthosis, and the extent of reduction was predicted by the fasting insulin level. During euglycemic insulin clamp testing, there was also evidence of resistance to exogenous insulin in the two patients so tested. As insulin resistance and the insulin binding defect worsened in the second patient, acanthosi nigricans remitted. We conclude that acanthosis nigricans is present in up to 5% of women with clinically significant hypertension.
Source link: https://doi.org/10.2337/diab.34.2.101
Hyperinsulinemia and decreased vivo responsiveness to insulin are two signs of persistent insulin resistance in young women without insulin-receptor autoantibodies. In monolayer culture, specific binding of insulin to skin fibroblasts was 49% higher than those in controls. The decreased autophosphorylation activity in cell lines from most subjects was out of proportion to reduced fibroblast insulin binding, according to individual reports, and it was 50% of the expected activity in 6 of the 12 cell lines.
Source link: https://doi.org/10.2337/diab.38.3.328
Acanthosis nigricans has been implicated in insulin resistance, according to insulin resistance. We aim to investigate AN from an endocrine and metabolic perspective, focusing on IR in association with metabolic diseases such as obesity, diabetes mellitus, and metabolic syndrome with or without polycystic ovary syndrome. PubMed updated English papers on PubMed, focusing on publications from the last five years. The newest prevalence of AN varies from 4. 5 to 74%, with equal distribution among females and males. Despite increased prevalence of obesity and MS in younger populations, an alarming rise in cases of obesity and MS has been noted. For example, in cases of sulcus cutis, hyperpigmented areas, crista cutis, and papillary tests, Dermoscopic examination is needed. A skin biopsy may be necessary, but it is not the norm. AN was associated with type2DM, as well as type 1DM. In 60% of cases, females with PCOS may already have metabolic problems, with an corresponding to the associated skin color. AN management is largely dependent on underlying conditions, and specific dermatological treatment is not often required, unless the patient reaches metabolic control, has severe skin lesions, or needs cosmetic enhancement. Lifestyle changes can benefit in IR situations, from weight control to bariatric surgery. Metformin, a drug whose effect is not limited to PCOS and even to ANS itself, is a key player in oral medication against DM type 2, a drug whose effect is also extended to PCOS and even to AN itself, outside of the specific panel of glucose anomalies.
Source link: https://doi.org/10.3390/diagnostics12102519
BACKGROUND Confluent and reticulated papillomatosis is a rare condition that is mostly present in young adults. METHODS We present a report of a 15-year-old male with multiple pigmented confluent, reticulated patches and plaques on neck, trunk, and chin for three years. CARP has been successfully treated with oral minocycline, resulting in complete resolution of lesions within two weeks, and patient embarrassment.
Source link: https://doi.org/10.2196/preprints.41245
BACKGROSIS nigricans is a canthosis nigricans' early detection because a canthosis nigricans can be a cutaneous manifestation of a variety of systemic diseases and, rarely as a sign of internal malignancy. Acanthosis nigricans' goal is to familiarize pediatricians with the clinical manifestations, diagnosis, and treatment of acanthosis nigricans. In this review, only papers that had been published in the English literature were included. Obesity, the most common cause of acanthosis nigricans, is increasingly present in obese children and adolescents, and can be a cutaneous marker of insulin resistance. Early detection of acanthosis nigricans is im-important because acanthosis nigricans may also be a sign of internal malignancy, and rarely as a sign of internal malignancy. Cosmetic reasons can be considered for patients with isolated acanthosis nigricans or those whose root cause is not amenable to treatment. Seldom, systemic therapy, such as oral retinoids, can be used for extensive or generalized acanthosis nigricans and acanthosis nigricans that are unresponsive to topical therapy. Although acanthosis nigricans is treatable, a complete cure is impossible to achieve. If possible, the root cause of acanthosis nigricans' recurrence should be addressed and avoided. Diagnosis can be difficult for lesions that have a standardized morphology or are in unusual location. Clinicians should be familiar with the clinical signs, diagnosis, and treatment of acan-thosis nigricans due to the connection between it and underlying diseases.
Source link: https://doi.org/10.2174/1573396318666220429085231
In Aravalli district of Gujarat state, the aim of the study was to determine the corresponding differences of metabolic factors, endocrine factors, and nutritional factors. The mean TSH value was found to be higher in an than in a control group at a 5 % level of significance, implying that hypothyroidism is correlated with AN. Patients with elevated blood glucose levels and some of the patients had elevated blood glucose levels, and some of the patients had a higher level of insulin. Positive correlations were found with elevated fasting glucose and hyperinsulinemia with AN and several other endocrine and metabolic related factors such as obesity and hypothyroidism, elevated glucose, and serum insulin were among the AN's. Thus, patients with AN can be targeted for lifestyle and behavioral changes at an early age to avoid the negative effects of AN.
Source link: https://doi.org/10.22376/ijpbs/lpr.2021.11.6.l1-7
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