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Acanthosis - MedlinePlus Genetics

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Last Updated: 10 December 2022

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Crouzon syndrome with acanthosis nigricans

acanthosis nigricans is a disorder that is related to premature attachment of certain bones of the skull during growth and a skin disease called acanthosis nigricans. The signs and symptoms of Crouzon syndrome with acanthosis nigricans are similar to those of a similar disorder called Crouzon syndrome. People with Crouzon syndrome or Crouzon syndrome with acanthosis nigricans have normal intelligence. Skin abnormalities are identified with acanthosis nigricans' acanthosis nigricans syndrome in Crouzon syndrome. Acanthosis nigricans, a skin disorder that causes thick, dark, velvety skin in body folds and creases, including the neck and underarms, is characterized by a skin disease. People with Crouzon syndrome with acanthosis nigricans may have additional skin abnormalities, such as scars in the thick, dark areas of skin, which are flat and pale.

Source link: https://medlineplus.gov/genetics/condition/crouzon-syndrome-with-acanthosis-nigricans


SADDAN

SADDAN is a rare condition of bone growth that is characterized by skeletal, brain, and skin abnormalities. Several affected individuals have also had episodes in which their breathing slows or stops for short stretches of time. Acanthosis nigricans, a progressive skin disorder characterized by thick, dark, velvety skin, is another typical feature of SADDAN that develops in childhood or early childhood.

Source link: https://medlineplus.gov/genetics/condition/saddan


Type A insulin resistance syndrome

Type A insulin resistance syndrome is a rare complication that is characterized by severe insulin resistance, a condition in which the body's tissues and organs do not respond appropriately to insulin. Diabetes mellitus is a medical disorder that can cause dangerously high blood sugar levels in people with type A insulin resistance syndrome, insulin resistance impairs blood sugar regulation, resulting in diabetes mellitus, which leads to diabetes mellitus. Type A insulin resistance syndrome is also related to other signs and symptoms of type A insulin resistance syndrome. Females with type A insulin resistance syndrome are usually not overweight, unlike most people with insulin resistance. In females, the signs of type A insulin resistance syndrome are more apparent. Type A insulin resistance syndrome is one of a group of related disorders that have been described as inheriting severe insulin resistance syndromes.

Source link: https://medlineplus.gov/genetics/condition/type-a-insulin-resistance-syndrome


Congenital generalized lipodystrophy

Congenital generalized lipodystrophy is a rare disorder with a complete absence of fatty tissue in the body and a muscular appearance. Congenital generalized lipodystrophy is one of a string of related disorders known as lipodystrophies, which are all associated with a lack of adipose tissue. Congenital generalized lipodystrophy is usually present from birth or early childhood. Insulin resistance can progress to a more severe disease called diabetes mellitus. Most affected individuals have elevated blood levels of triglycerides, which may contribute to the formation of small yellow deposits of fat under the skin that can lead to small yellow patches of fat under the skin, eruptive xanthomas, and pancreas inflammation. In addition, congenital generalized lipodystrophy causes an abnormal accumulation of fats in the liver, which can lead to an enlarged liver and liver failure. Hypertrophic cardiomyopathy, some of the patients' heart disease, can cause heart failure and an irregular heart rhythm that can cause sudden death. People with congenital generalized lipodystrophy have a distinct physical appearance. Many people with this disorder have acanthosis nigricans, a skin disorder related to elevated blood insulin levels. Acanthosis nigricans causes the skin in body folds and creases to become thick, dark, and velvety. For example, some people with congenital generalized lipodystrophy type 1 develop cysts in the long bones of the arms and legs after puberty, as shown above.

Source link: https://medlineplus.gov/genetics/condition/congenital-generalized-lipodystrophy


Familial partial lipodystrophy

Familial partial lipodystrophy is a rare condition characterized by an abnormal pattern of fatty tissue. Adipose tissue can be found in numerous areas of the body, including under the skin and around the internal organs. Health issues in adulthood can arise from abnormal fat storage in the body. Insul resistance is a condition in which the body's tissues are unable to properly respond to insulin, which is a hormone that normally helps regulate blood sugar levels. Many people with familial partial lipodystrophy develop insulin resistance, a condition in which the body's tissues do not respond properly to insulin. insulin resistance is a marker that helps regulate blood sugar levels. Insulin resistance may exacerbate to the point of being a more severe condition called diabetes mellitus. Some people with partial lipodystrophy develop acanthosis nigricans, a skin disorder characterized by elevated insulin levels in the bloodstream. Acanthosis nigricans causes the skin in body folds and creases to become thick, dark, and velvety. In the bloodstream, the majority of people with familial partial lipodystrophy also have elevated amounts of fatty acids called triglycerides, which may contribute to pancreas inflammation. Familial partial lipodystrophy can also cause an abnormal accumulation of fats in the liver, which may lead to an elevated liver and abnormal liver function. type 2 is the most common cause of familial partial lipodystrophy, also known as Dunn. . . n disease. Some people with this condition develop muscle weakness, abnormalities of the heart muscle, a type of heart disease, artery disease, and cardiac rhythm problems with the heartbeat's electrical system.

Source link: https://medlineplus.gov/genetics/condition/familial-partial-lipodystrophy


Alström syndrome

Some people with Alstrence nigricans syndrome have a skin disorder that causes the skin in body folds and creases to become thick, dark, and velvety. AstrU00f6m syndrome's signs and symptoms vary, and not all affected individuals have all of the disorder's characteristic features.

Source link: https://medlineplus.gov/genetics/condition/alstrom-syndrome


X-linked acrogigantism

Babies with this disorder are a normal size at birth, but they begin to grow rapidly in infanthood or early childhood, and the affected children are taller than their peers. Individuals with X-LAG may have the condition as a result of either enlargement of the gland or the emergence of a noncancerous tumor in the gland. An adenoma and pituitary hyperplasia are rare in an affected individual. Growth hormone releasing hormone - a hormone that is produced by a portion of the brain called the hypothalamus - is present in certain people with X-LAG. Some people with X-LAG have additional signs and symptoms such as facial skin and feet;disproportionately large hands or feet; and an increased appetite; and a skin disease called acanthosis nigricans, in which the skin in body folds and creases becomes thick, dark, and velvety.

Source link: https://medlineplus.gov/genetics/condition/x-linked-acrogigantism

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions