Advanced searches left 3/3

Acanthosis - Crossref

Summarized by Plex Scholar
Last Updated: 10 January 2023

* If you want to update the article please login/register

Clinical signs, interventions, and treatment course of three different treatment protocols in patients with Crouzon syndrome with acanthosis nigricans

Crouzon syndrome with acanthosis nigricans is a rare and medically fragile subtype of Crouzon syndrome. This multicenter investigation was conducted at three craniofacial centers in order to determine clinical results in connection with the required interventions and treatment regimen in patients with CAN. CONCLUSIONS The study found that patients with the mutation c. 1172C > A in the FGFR3 gene have a pronounced disease course, necssitating multiple surgical procedures. It was difficult to distinguish the effect of a more severe clinical presentation from the effects of a specific medical condition on outcome.

Source link: https://doi.org/10.3171/2021.2.peds20933


Acanthosis Nigricans in Patients with Type II Diabetes Mellitus at a Tertiary Care Hospital of Lahore

The aim of this research was to determine the presence of Acanthosis Nigricans among patients of type II diabetes mellitus. This observational cross-sectional research was conducted at Department of Medicine Azra Naheed Medical College, Superior University Lahore, from August 2021 to April 2022. Patients with type II diabetes mellitus were classified as patients with HbA1c 7. 0%, two blood glucose random readings of =200 mg/dl, or previous history of diabetes treatment, or taking anti-hyperglycemic drugs. Acanthosis Nigricans was identified as having more than 2 cm poorly defined hyperpigmented skin lesions of brownish black color and velvety texture over the nape of neck, axillae, and/or groin. Following informed permission, 340 patients of type II diabetes mellitus aged 30-75 years of both gender were enrolled in a nonprobability consecutive sampling method. Acanthosis Nigricans was present in over half of type II diabetes mellitus patients, according to the author.

Source link: https://doi.org/10.51985/jbumdc202266


CLINICO-DEMOGRAPHIC STUDY OF PATIENTS WITH ACANTHOSIS NIGRICANS

Acanthosis Nigricans is a common skin pigmentary disorder with a velvety texture, and it is distributed on the neck, axillae, antecubital, and popliteal fossae, and groin folds. We have Aim - done this to investigate the prevalence, socioeconomic, and etiological prognosis of patients with Coronary heart disease -related Coronary heart disease. In 12 patients, six patients had systolic hypertension and diastolic hypertension. Coronary Heart Disease patients with AN, who have high BMI, are more likely to develop hypertension, according to the most common symptoms of Coronary Heart Disease. High blood pressure in AN is consistent with systolic hypertension, but there is no evidence that LDL is related to any of systolic or diastolic hypertension in AN.

Source link: https://doi.org/10.36106/ijsr/6411615


Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model

Abstract The epidermis is a flexible tissue in which keratinocytes proliferate in the basal layer and undergo a strict controlled differentiation as we progress to the suprabasal layers. We've looked at the possibility of the flavone Luteolin-7-glucoside as a treatment for psoriasis here. In HEKn, the proinflammatory cytokines IL-22 and IL-6 have also neutralized the proliferative response induced by the proinflammatory cytokines IL-22 and IL-6. In addition, topical administration of LUT-7G in the Imiquimod mouse model of psoriasis results in a marked decline of acanthosis and re-expression of epidermal differentiation markers. The LUT-7G impairs the nuclear translocation of phosphorylated STAT3-phosphatated STAT3 in the IL-22 signalling pathway, which is triggered by IMQ therapy, blocking the IL-22 signalling cascade. Thus, LUT-7G appears to be a promising drug for the treatment of hyperproliferative and inflammatory skin diseases, including psoriasis.

Source link: https://doi.org/10.1038/cddis.2016.201


Hypochondroplasia and acanthosis nigricans: a new syndrome due to the p.Lys650Thr mutation in the fibroblast growth factor receptor 3 gene?

Hypochondroplasia is a skeletal dysplasia inherited in an autosomal dominant manner, in the majority of cases, thanks to mutations in the fibroblast growth factor receptor 3 gene. Acanthosis nigricans is a velvety and papillomatous pigmented hyperkeratosis of the skin that has been present in certain genetic disorders that involve the FGFR3 gene. The p. Lys650Thr mutation was seen in HCH plus AN and the investigation of FGFR3. p. Lys650Thr, the first report of a large pedigree with the phenotype of HCH plus AN due to a FGFR3 mutation. Both conditions can coexist due to the same mutation, and it could be a true mystery, which should be further investigated by looking for AN in mild HCH patients or HCH in patients with AN.

Source link: https://doi.org/10.1530/eje-08-0393


Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis

The human tissue collagenase gene was expressed in the suprabasal layer of the skin epidermis in a series of transgenic mice. In the human skin diseases of lamellar ichthyosis, atopic dermatitis, and psoriasis, despite a variety of underlying etiologies, similar morphological hyperproliferative changes in the epidermis are present. When the transgenic mouse skin was first treated with an initiator and then twice weekly with a promoter, there was a significant rise in tumor incidence among transgenic mice relative to that among control littermates.

Source link: https://doi.org/10.1128/mcb.15.10.5732

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions