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The Global Initiative for Chronic Obstructive Lung Disease's Report examines blood eosinophil counts in people with COPD to predict poor inhaled corticosteroid responsiveness. Is there a difference between GOLD Group D patients with high BEC and those with low BEC in terms of baselines' characteristic and longitudinal outcomes? BEC >100 in all COPD studies and GOLD Group D not on ICS, respectively, used multivariable mixed models and logistic regression to compare clinical characteristics and results of BEC u2264100 versus BEC > 100 in all COPD studies, as well as GOLD Group D not on ICS. Results We found n=485 with BEC u2264100 and n=929 people with BEC 100+. However, in GOLD Group D, BEC u2264100 individuals, the higher exacerbation rates increased within 365 days after enrollment and a complete follow-up. Interpretation gOLD Group D COPD, indviduals with BEC u2264100 had more baseline emphysema, prospective exacerbations, and lung function decline than non-ICS-treated BEC u2264100.
Source link: https://europepmc.org/article/MED/36343688
Background Due to the predominance of immunotherapy in advanced non-small cell lung cancer, immunotherapy-related adverse events have drew a lot of attention lately. The occurrence of irAEs in Chinese NSCLC patients was investigated in this paper, as well as potential risk factors for the emergence of severe irAEs. Baseline peripheral absolute eosinophil count was found to be a direct predictor of high-grade irAEs by multivariate analysis. Patients with severe irAEs had a poorer OS, according to a survival review.
Source link: https://europepmc.org/article/MED/36313675
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