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Abnormal Bleeding - Europe PMC

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Last Updated: 03 November 2022

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National survey of abnormal uterine bleeding according to the FIGO classification in Japan.

Aim To examine abnormal uterine bleeding in Japan using the International Federation of Gynecology and Obstetrics classification to help identify the connection between AUB symptoms and the diseases that cause AUB. Methods In a nationwide survey, we enrolled first-time patients who visited target facilities in two weeks from December 1, 2019 to January 31, 2020, as part of a national survey. PALM had the highest percentage of AUB-O's in the study, with AUB-L and COEIN having the highest percentage of AUB-O. COEIN was strongly associated with abnormal menstrual cycles and PALM with abnormal menstrual bleeding, according to a Correspondence review. PALM-COEIN's FIGO classification was a valuable diagnostic tool for AUB diagnosis, with a strong correlation between symptoms of AUB by AUB system 1 and the causative disease of AUB. AUB system 1 and PALM-COEIN, on the other hand, are ambiguous as diagnostic tools.

Source link: https://europepmc.org/article/MED/36258286


Whole-exome sequencing reveals novel variants associated with abnormal uterine bleeding caused by copper intrauterine device.

Aim: This research sought to determine the genetic risk factors and identify variants of abnormal uterine bleeding after the introduction of a copper intrauterine device. NFASC RS2802808 C > G p. Ile971Met and PIGR RS2275531 C > T p. Gly365Ser variants were found as significantly associated with abnormal uterine bleeding with a false discovery rate of 0. 05, based on combined study of screening and validation.

Source link: https://europepmc.org/article/MED/36250535


Association between isolated abnormal coagulation profile on transfusion following major surgery: A NSQIP analysis of individuals without bleeding disorders.

We investigated the relationship between abnormal coagulation profile and the risk of transfusion after common elective surgery in patients with bleeding disorders. Methods and design of the study The National Surgical Quality Improvement Program database was used from 2004 to 2018 to identify patients with a history of bleeding disorders undergoing common 23 major elective procedures in ten specialties. A multivariable logistic regression was used to investigate the connection between coagulation profile and bleeding in patients requiring packed red blood cell transfusion intra-/post-operatively. Both Abnormal INR/aPTT and Low PLT of 60,000 were present, with a synergistic effect of combinatorial lab abnormalities on the risk of transfusion, according to the effects of Abnormal INR/aPTT and Low PLT, which is compared to normal/elevated PLT. Discussion The preoperative presence of abnormalities in INR or PLT was highly associated with the danger of bleeding requiring transfusion during intraoperative and postoperative periods.

Source link: https://europepmc.org/article/MED/36250486

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions