Advanced searches left 3/3

Abdominal Sepsis - Europe PMC

Summarized by Plex Scholar
Last Updated: 05 November 2022

* If you want to update the article please login/register

S100A9 induces reactive oxygen species-dependent formation of neutrophil extracellular traps in abdominal sepsis.

According to latest reports, targeting S100A9 can reduce pathological inflammation in abdominal sepsis. We investigated the role of S100A9 in neutrophil extracellular trap formation in septic lung damage herein. NETs were created by the stimulation of isolated mouse bone marrow-derived neutrophils from S100A9, triggering the formation of NETs. Moreover, S100A9's failure raised the generation of reactive oxygen species in bone marrow neutrophils in comparison to S100A9. In S100A9-stimulated neutrophils, co-incubation with the NADPH oxidase inhibitor not only reduced ROS formation but also attenuated induction of DNA-histone complexes. In male C57BL/6 mice, cecal ligation and puncture was triggered. We found that local injection of NETs in the mouse cremaster muscle microvasculature increased leukocyte adhesion and migration. We used intravital microscopy to determine mouse microvasculature. Unlikely, NET-induced leukocyte adhesion and extravasation in the cremaster muscle slowed during treatment with ABR-238901 (notably), indicating that NET-associated S100A9 aids leukocyte recruitment in vivo. Hence, targeting S100A9 could be helpful to reduce lung damage in abdominal sepsis.

Source link: https://europepmc.org/article/MED/36328195


The Prediction of Surgery Outcomes in Abdominal Tumor Patients with Sepsis by Pcv-aCO2/Ca-cvO2.

Patients' outcomes and mortality were not predicted by hemodynamic parameter alone, but a 72-hour SOFA score could indicate patient outcome and mortality. After standard fluid resuscitation, the treatment result was not positive, according to the Kaplan-Meier univariate survival curve and Log-rank, patients with a higher combined predictive parameter of T3 Ratio + T3 Pcv-aCO2 showed ischemia and hypoxia of tissues and organs after standard fluid resuscitation, and the treatment result was not satisfactory. Conclusion After abdominal tumor surgery, Ratio and Pcv-aCO2 may have been combined to determine clinical care of patients with abdominal infection and sepsis.

Source link: https://europepmc.org/article/MED/36238956

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions