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Abdominal Aneurysm - Europe PMC

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Last Updated: 10 December 2022

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Abdominal aortic aneurysm and exfoliation syndrome: A literature review comparing single site findings.

Multiple research have suggested a possible connection between exfoliation syndrome and abdominal aortic aneurysm. Half of the studies investigated AAA prevalence in a population with or without XFS, while the other half explored the opposite. XFS was a risk factor for AAA's development, according to three research, and the other three found this association to be inconclusive. A large database of XFS and AAA patients could be useful in determining if an association does in fact exist.

Source link: https://europepmc.org/article/MED/36482872


Plasma complement component C2: a potential biomarker for predicting abdominal aortic aneurysm related complications.

Patients and non-AAA patients presenting to St. Michael's Hospital in consecutive AAA patients and non-AAA patients. Both baseline and prospectively measured every 2 years were evaluated at baseline, as well as prospectively monitored regularly over a period of two years. Patients with AAA were compared to multivariable adjusted Cox regression studies to determine the prognostic value of plasma C2 levels in patients with AAA concerning rapid aortic expansion, MAAE, and MACE. Patients with AAA had significantly higher blood counts of C1q, C4, Factor H, and Factor D, compared to non-AAA patients, with substantially lower plasma concentrations of C2, C3, and C4b. Based on the results from the survival study, higher C2 levels at admission in patients with AAA predicted a greater risk of rapid aortic expansion and MAAE. Plasma C2 has the capability to be a biomarker for predicting rapid aortic expansion, MAAE, and the eventual need for an aortic intervention in AAA patients.

Source link: https://europepmc.org/article/MED/36482198


The role of integrins in atherosclerosis complicated with abdominal aortic aneurysm: A bioinformatics study

Methods The aim of our research was to identify the hub genes involved in the pathogenesis of atherosclerosis and AAA. Our analysis was based on two gene expression profiles for atherosclerosis and AAA, which were downloaded from the Gene Expression Omnibus database. Differential genes were identified and an enrichment analysis of differential genes was performed, along with the establishment of protein-protein interaction networks and the identification of common hub genes and predicted transcription factors. Conclusions The study found 133 differentially expressed genes, with the enrichment analysis highlighting a potential role for integrins and chemokines in common immune and immune responses of atherosclerosis and AAA. Both diseases were associated with the regulation of the complement and coagulation cascades, as well as the control of the actin cytoskeleton, including ten key hub genes: TYROBP, PTPRC, ITGB2, ITGAM, PLEK, CTSS, LY86, ITGAX, CCL4, and FCER1G.

Source link: https://europepmc.org/article/PPR/PPR581064


Dying to Get There: Patients Who Reside at Increased Distance from Tertiary Center Experience Increased Mortality Following Abdominal Aortic Aneurysm Rupture.

Objective Centralization of vascular surgery care for Ruptured Abdominal Aneurysms to high volume tertiary centers can reduce access to emergency surgical intervention for patients in rural areas. In the province of Nova Scotia, Canada, the aim of this research was to determine the relationship between distance from vascular care and mortality from RAAA. To determine the independent effect of travel time on survival outcomes, a multivariable logistic regression model was used to calculate the independent effect of travel time on survival outcomes. Results of a survey conducted in 2005-2015 A total of 567 patients with RAAA were identified from 2005-2015, of which 250 lived 1 hour travel time to the tertiary center, and 317 people resided u22651 hour. However, there was no difference in the overall likelihood of surviving between patients undergoing AAA repair or surgery. Patients with RAAA can therefore be aided in early detection and timely transfer to a vascular surgery center.

Source link: https://europepmc.org/article/MED/36481675


Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

AAA shows the hallmarks of an autoimmune disease, according to new evidence, and specific antigen-driven T cells in the aortic tissue may have influenced the initial immune response. Here, we perform a representative review of experimental murine AAA's scRNA TCR and BCR sequencing results, revealing a robust and streamlined bioinformatic processing pipeline that highlights the advantages and disadvantages of this strategy. Neither within the disease stages nor between AAA and control showed any differences between AAA and control cells and 796 T cells in a comparative analysis. In AAA, we discovered no clonal expansion of B cells. TRBV3, TRBV19, and TRBV13-2 are the most commonly used V-genes in the TCR beta chain in AAA.

Source link: https://europepmc.org/article/PPR/PPR579612


Identification and Experimental Validation of Autophagy-Related Genes in Abdominal aortic aneurysm: a bioinformatics analysis

Aim: Autophagy plays a significant role in abdominal aortic aneurysm formation and movement. Methods The GEO database contains two gene expression profile datasets. And, finally, RT-qPCR was used to determine the RNA expression levels of the top five hub genes in clinical samples. The expression of IL6, PPARG, SOD1, and MAP1LC3B in AAA cases and negative control were in accordance with the bioinformatic analysis findings, according to the RT-qPCR findings. Conclusion Hub genes such as IL6, PPARG, SOD1, and MAP1LC3B can have a role in AAA's success by regulating autophagy.

Source link: https://europepmc.org/article/PPR/PPR579247


Platelets modulate inflammation and matrix remodeling in abdominal aortic aneurysm

Abdominal aortic aneurysm is a fatal disease with progressive dilatation of the abdominal aorta as a result of tissue destruction and reconstruction of the vessel wall due to chronic inflammation. Platelets are important in cardiovascular disease, but their role in AAA is unclear. Platelet depletion in experimental murine AAA reduced inflammation and ECM remodeling, with reduced elastin fragmentation and aortic diameter expansion, as measured. In conclusion, our research points to the fact that anti-platelet therapy may have a lot of promise to reduce AAA progression and rupture in AAA patients.

Source link: https://europepmc.org/article/PPR/PPR578913


Follow-up Results of Endovascular Aneurysm Repair Following Abdominal Visceral Debranching.

Methods Between May 2015 and December 2018, the records of six patients with thoracoabdominal aneurysms and other comorbidities who underwent endovascular aneurysm repair were reviewed retrospectively. Debranching was performed from the right iliac artery in one patient who underwent coronary artery bypass grafting. In three patients, three visceral arteries were blocked in one of three patients, and two visceral arteries were performed in two patients. In one and five patients, respectively, for debranching, grafts were used in a Great saphenous vein and 6-mm polytetrafluoroethylene grafts. Following debranching procedures as soon as the patients were stable, endovascular aneurysm repair was performed. Conclusion The procedure, however, requires experience and care, and it can be a viable alternative to fenestrated or branched endovascular stent grafts in patients with elevated risk factors for open surgical thoracoabdominal aneurysm repair.

Source link: https://europepmc.org/article/MED/35436072


Characteristics Associated With Failure to Rescue After Open Abdominal Aortic Aneurysm Repair.

Introduction Failure to Rescue, which is defined as death as a result of a care-complication, is a key indicator of hospital care quality. Understanding risk factors related to FTR in the elective Abdominal Aneurysm population may help surgeons minimize surgical mortality. Elective open AAA repairs were identified from Cerner's HealthFacts database using ICD-9 and ICD-10 diagnosis and procedure codes, as shown by the clinician's HealthFacts database. The relative contribution of patient and encounter characteristics that resulted in FTR was determined by multivariate logistic regression models. The incidence of nonruptured AAA in 1761 patients underwent open repair for nonruptured AAA was 6. 1%. Patients with one or two disorders accounted for 9. 6%, compared to 21. 5 percent for patients with u22654 major complications. Myocardial infarction, digestive bleeding, and respiratory failure were all common problems of care related to death. Adopting gender-specific assessment software, a protocol-driven strategy for perioperative GI prophylaxis, and preoperative MI risk minimization may result in reduced FTR.

Source link: https://europepmc.org/article/MED/36459861


Reliability of the modified Frailty Index (mFI) for intervention and continued surveillance in elective infrarenal abdominal aortic aneurysm (AAA).

The aim of the study was to determine if the mFI correlates with clinician experiences in treating patients for abdominal aortic aneurysm surgery and/or AAA monitoring. Methods The aim of this paper was to find a contemporaneously organized registry of all AAA patients treated at a large University Hospital during 2017 review. Patients were divided into the following groups; ongoing surveillance, turned down for tracking, patient declined surveillance, patient refused monitoring, patient refused care, patient turned down for surgery, and patient refusal surgery were all divided into the following categories; patient outcomes were divided into the following groups; patient declined surgery; patient turned down for surgery; patient declined surgery; patient refused to recover; patient declined surgery; patient declined surgery; and patient refused surgery were patients. With a median mFI of 0. 36, eighteen patients > 5. 5 cm were turned down for surgical intervention. A median mFI of 0. 09 was obtained in Forty-two patients undergoing surgical intervention. Conclusions Frailty is correlated with elevated morbidity and mortality amongst frail patient cohorts. mFI is a reliable and simple to use device that can predict perioperative outcomes in AAA intervention studies.

Source link: https://europepmc.org/article/MED/36456412

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions