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We assumed a link between the humoral adaptive immune response and microglial activation in α-SYN induced neurodegeneration. To test this hypothesis, we used adeno-associated infection serotype 2 to uniquely over-express human α-SYN in the substantia n.... of wild-type mice and FcγR-/- mice, which lack high-affinity receptors for IgG. We discovered that in wild-type mice, α-SYN induced the expression of NF-κB p65 and pro-inflammatory particles. α-SYN overexpression caused the look of dysmorphic neurites, and a loss of DA neurons in the SN in wild-type animals, while FcγR-/- mice did not display neuritic adjustment and were safeguarded from α-SYN-induced neurodegeneration 24 weeks after shot. Our results suggest that the humoral adaptive immune response set off by excess α-SYN plays an original duty in microglial activation with IgG-FcγR interaction.
Source link: https://doi.org/10.1186/1750-1326-5-42
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