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Atp Synthesis - Europe PMC

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Last Updated: 10 July 2022

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Liposomal Form of 2,4-Dinitrophenol Lipophilic Derivatives as a Promising Therapeutic Agent for ATP Synthesis Inhibition.

2,4-dinitrophenol, Mitochondrial uncoupler 2,4-dinitrophenol, is a promising antibiobetic and antiobesity agent. Using carboxylic acid chloride, we created 2,4-DNP esters with carboxylic acids of various lipophilic degrees and then packed them into liposomes. When esters were used, we demonstrated the efficient increase in the entrapment of 2,4-DNP into liposomes. Here, we investigated the relationship between 2,4-DNP from liposomes' steady release of 2,4-DNP from liposomes in this respect, based on the ester's lipid composition and LogP oct. According to We recommend that the optimal chain length of the ester should be near to the palmitic acid and the lipid membrane should be composed of phospholipids with a specific phase transition point, depending on the desired release rate. The increased effect of the ATP synthesis inhibition of the liposomal forms of caproic and palmitic acid esters in liver hepatocytes was shown by the compared to free molecules.

Source link: https://europepmc.org/article/MED/35808003

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions