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ATP Synthase - DOAJ

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Last Updated: 10 August 2022

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DJ-1 interacts with the ectopic ATP-synthase in endothelial cells during acute ischemia and reperfusion

Endothelial cells play a key role in ischemia. During acute ischemia and I/R in ECs, we concentrated on the description of DJ-1's endothelial kinetics and its role in the regulation of the ectopic ATP-synthase production. DJ-1 was only discovered in the elusiveome of ischemic cells, a cleaved version of DJ-1. Following acute ischemia in ECs, the eccept-S activity soared, coinciding with DJ-1 and DJ-2206C secrecy. The inhibition of DJ-1 expression slowed the ecATP-S response to ischemia by a whopping 50%, and its exogenous administration maximized the effect, as well as an improved Akt phosphorylation and angiotube-formation potential at reperfusion. The ecATP-S study demonstrated a clear correlation between DJ-1 and the ecATP-S. During acute ischemia and reperfusion, Altogether says that DJ-1 is specifically cleaved and released from ischemic ECs and plays a key role in the establishment of the ecATP-S activity.

Source link: https://doi.org/10.1038/s41598-022-16998-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions