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The apolipoprotein E-deficient mice, a 5/6 nephrectomy or a sham surgery at 8 weeks of age, were then treated or not with oral AST-120 for 12 weeks. In the 5/6 NR group, the expression of sFlt-1 mRNA in the kidney was significantly lower than in the sham group, but AST-120 treatment reversed this decrease in sFlt-1 levels. Similar to the sham group, the atherosclerotic plaque area of the thoracoabdominal aorta was much larger in the 5/6 NR group than in the sham group, and AST-120 therapy stopped this rise in atherosclerosis.
Source link: https://doi.org/10.1038/s41598-019-51292-9
Flavonoids in Sumbawa forest honey are an antioxidant that neutralizes the body's excess free radicals. Lead acetate-induced rats' liver histopathology and AST-ALT levels were determined by this study. The forest honey Sumbawa dose 75 mg/kg BW was able to prevent ALT-AST elevation by a significant degree and reduced liver tissue damage in rats exposed lead, according to the study. Due to Lead exposure, the Sumbawa forest honey could be used as a preventative to prevent liver disease.
Source link: https://doi.org/10.1088/1742-6596/1430/1/012030
Abstract Carbon tetrachloride is one of the hepatotoxic substances that can cause hepatic fibrosis. LCl 4 is a member of the Federation of South Africa The purpose of this study was to determine the contribution of fermented soybean to IL-6 expression and ALT-AST levels in rats. The study revealed that 800 mg/kg BW was an effective dose that resulted in the highest percentage reduction of hepatic IL-6 expression and ALT-AST level 81,16% and 46,45% respectively, which were at 56% and 45,45% respectively, as well as a 65% decrease. In experimental CCl 4 rats, the fermented of soybean was able to reduce the hepatic IL-6 expression and ALTAST levels.
Source link: https://doi.org/10.1088/1742-6596/1430/1/012019
A total number of 192 male one-day-old broilers chickens were randomly divided into four treatment groups of 48 chickens. Chickens of group one were fed a plain diet with no supplements, while the ib groups two, three, and four were supplemented with Whole Yeast, Yeast Cell Wall, and Yeast Extract respectively, respectively. At the end of the experimental period, the bodyweight of chickens and the feed intake of each cage were determined, and then the feed consumption ratio was calculated. The treated groups had a significant elevated serum total protein and albumin, as well as significantly lower serum total lipids and cholesterol, according to blood tests. It can be shown that supplementation of WY or its derivatives in the diet of broiler chickens improves production results as well as the physical and immunological characteristics, resulting in a healthier chicken.
Source link: https://doi.org/10.54203/scil.2021.wvj33
Abstract Purpose HCC patients typically have a complicated tumor stage in which surgical procedures are not appropriate. Screening ultrasound exams can raise the number of patients with small tumors diagnosed with small tumors, but are often not used in patients at risk of HCC. Methods An examination was done of commonly used blood count and liver function parameters in a group of patients with small HCCs or no HCC who underwent liver transplantation in our center. The HCC patients were found to be significantly different among the two HCC groups, as well as blood total bilirubin, ALKP, and PLR ratio. Conclusion: The combination of elevated blood counts of lymphocyte counts and AST values has promise for the screening of patients with chronic liver disease who are at risk of HCC.
Source link: https://doi.org/10.21203/rs.3.rs-977191/v1
In Wistar rats, the aim was to determine the hepatic harm induced by the E. mathaei ethanol extract on high-dose paracetamol-induced hepatic damage. For three days, Thirty white male rats were divided into sixth groups, i. e. , a standard control group, group II–VI was introduced paracetamol 2,000 mg/kg BW for three days. At a dose of 800 mg/kg BW per orally treated, E. mathaei significantly reduced the AST, MDA levels, and the number of hepatocyte necrosis cells. Conclusions The E. mathaei ethanol extract repaired the hepatic damage caused by paracetamol.
Source link: https://doi.org/10.1515/jbcpp-2020-0420
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