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AST ALT Ratio - Crossref

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Last Updated: 10 August 2022

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AST/ALT ratio as a predictor of mortality and future exacerbations of PM/DM-ILD——a retrospective cohort study with 522 cases

Plastitis/dermatomyositis-associated interstitial lung disease patients with Polymyositis/dermatomyositis-related interstitial lung disease (DRR) at West China Hospital of Sichuan University from January 1, 2008 to December 31, 2018. Objectives and MethodsThis was a retrospective cohort study that looked at the correlations between aspartate transaminase ratio and mortality in patients with Polymyositis/dermatomyo In a one-year follow-up, patients with elevated DRR and hospitalization were more likely to die, risk of mechanical ventilation, and hospitalization.

Source link: https://doi.org/10.21203/rs.3.rs-25060/v1


Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy: Results from a single-institutional series

Background: Bladder cancer staging is difficult. In the prediction of locally-advanced disease defined as the presence of extravescical extension and/or lymph node metastases in patients with BC treated with radical cystectomy, the objective: To determine the role of the De Ritis ratio and neutrophils to lymphocyte ratio. Methods: We retrospectively analyzed clinical and pathological data of 139 consecutive patients who underwent RC at our hospital. Our institution's RC program featured a total of 139 consecutive patients. Patients with locally-advanced disease were significantly higher in patients with locally-advanced disease than those with organ-confined disease. Patients with a DRR > 1. 21 were at a greater risk of locally infectious disease in univariate LRMs. In patients with NLR > 3. 47, there was also an elevated risk of locally acquired disease. AUC of the multivariate LRM was 0. 707 in assessing the possibility of locally acquired disease.

Source link: https://doi.org/10.1177/03915603211035191


Population Pharmacokinetic Model of AST-001, L-Isomer of Serine, Combining Endogenous Production and Exogenous Administration in Healthy Subjects

AST-001 is an L-isomer of serine that has anti-inflammatory properties on neurological disorders. This study was designed to establish a population pharmacokinetic model of AST-001 in healthy Koreans in order to further introduce a fixed-dose regimen in pediatrics. After a single dose of 10, 20, and 30 g of AST-001, the model was created using 648 plasma concentrations from 24 healthy patients, as well as baseline endogenous levels during 24 h and concentrations. A two-compartment model with zero-order absorption and linear elimination was a good representation of the PK characteristics of AST-001 following oral administration. The new population PK model accurately represented both observed endogenous production and exogenous administration of AST-001 in healthy subjects. We found an optimal fixed-dose regimen with five weight ranges in pediatrics for the forthcoming phase 2 trial using the allometric scaling method.

Source link: https://doi.org/10.3389/fphar.2022.891227


Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

Abstract This research is designed to explore the connection between the aspartate amino transferase /alanine aminotransferase ratio and all-cause mortality in stable coronary artery disease patients treated by percutaneous coronary intervention. ACM was present in 6 patients in the low group and 12 patients in the high group, with significant differences between the two groups. An elevated AST/ALT ratio was associated with elevated ACM in stable ACD patients, according to the Kaplan-u2013Meier study. Thus, an elevated AST/ALT ratio in stable ACD patients is an independent prognostic factor for ACM.

Source link: https://doi.org/10.1038/s41598-022-13355-2


Elevation of AST/ALT Ratio in Association with Severity of Esophageal Varices in Patients with Hepatic Cirrhosis

Object: To determine the AST/ALT ratio in patients with hepatic cirrhosis, with the severity of esophageal varices. In 20. 9% grade II, the Paquet grading system showed that esophageal varices were present in 20. 9% grade II. Patients of liver cirrhosis with esophageal varices were at a 27 percent risk of esophageal varices within the 65 cases of esophageal varices. Conclusion: The elevated ALT and AST levels in hepatic cirrhosispatients are significantly associated with the occurrence of esophageal varices.

Source link: https://doi.org/10.53350/pjmhs22165259


AST/ALT (De Ritis) Ratio in Early Stage Differentiated Thyroid Cancer

The most common endocrine tumors, differentiated thyroid cancers, are the most common endocrine cancers, and their prevalence is on the rise in imaging methods. We wanted to see if there is a correlation between histopathological subtype, multifocality, disease stage, and risk group in early stage thyroid cancers, according to this report. The study included a total of 154 patients with differentiated thyroid cancer in our clinic between 2016 and 2019. The association between the patients' preoperative De Ritis rates and postoperative staging was investigated. Patients with a De Ritis rate of u22651. 5 were 15. 9% in the hospital. Conclusion: The preoperative De Ritis ratio was not related to disease stage and risk status in early stage differentiated thyroid cancers, according to the authors.

Source link: https://doi.org/10.30934/kusbed.1009993


External validation of preoperative AST/ALT (De-Ritis) ratio as a prognostic indicator in localized and metastatic renal cell carcinoma.

589 Background: The De-Ritis ratio, which is the ratio of preoperative aminotransferase to alanine aminotransferase in a European cohort with localized renal cell carcinoma, was found to be an early predictor of overall and recurrence-free survival in a 589 study. Emory Nephrectomy Database searches patients who underwent nephrectomy for localized and metastatic RCC between 2001 and 2014, with available laboratory results within one week of surgery. Conclusions: Elevated De-Ritis ratio is a reliable and reliable predictor of overall and recurrence-free survival, and it is capable of distinguishing high-risk disease in patients with localized and metastatic RCC. These findings are consistent with a previous study that looked at the prognostic value of the De-Ritis ratio in a European cohort, as well as proving its prognostic value in a geographically distinct group of patients with metastatic disease [Table: see text]. [Table: see text] These results are consistent with a previous analysis that determined the prevalence of the disease in a population-based cohort of patients with metastatic disease. [Table: see text].

Source link: https://doi.org/10.1200/jco.2016.34.2_suppl.589


The significance of transaminase ratio (AST/ALT) in acute myocardial infarction

We wanted to investigate the AST/ALT ratio changes in patients with acute myocardial infarction in the Chinese Han population with no history of liver disease. Between January 2019 and June 2019, we analyzed a total of 120 patients with acute myocardial infarction admitted to Wuhan University's cardiology department. The first blood test's AST/ALT ratio was determined for all patients. In patients with ST-egment elevation myocardial infarction and non-ST-segment elevation myocardial infarction patients, the mean De Ritis ratio was higher.

Source link: https://doi.org/10.5114/amsad.2020.103028

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions