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AST ALT - Crossref

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Last Updated: 10 August 2022

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Prognostic Significance of ALT/AST in diabetic patients having Myocarditis secondary to COVID Pneumonia

Aim: To determine the predictive value of raised ALT/AST ratio in diabetic patients for survival and myocarditis due to COVID-19 pneumonia. Methods: At Services Hospital in Lahore, a cross-sectional research was conducted for six months. It was a cross-sectional study conducted for six months. In blood, a total of 350 patients will be tested for ALT and AST levels. Patients with myocarditis and ALT/AST ratios lower than 0. 90 had a dismal prognosis. The ALT/AST ratio u2019s performance, specificity, PPV, NPV, and diagnostic accuracy were 78%, 42. 9%, 20%, 91. 3%, and 48. 3% for predicting diabetic patients with COVID-19 pneumonia-related myocarditis. Conclusion: This study revealed that the ALT/AST ratio is not a good predictor of mortality in diabetic patients with COVID-related myocarditis.

Source link: https://doi.org/10.53350/pjmhs22167121


Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy: Results from a single-institutional series

Background: Bladder cancer staging is difficult. In the prediction of locally-advanced disease identified as the presence of extravescical extension and/or lymph node metastases in patients with BC treated with radical cystectomy, the De Ritis ratio and neutrophils to lymphocyte ratios must be determined. Methods: We retrospectively reviewed the clinical and pathological results of 139 consecutive patients who underwent RC at our hospital. Patients with locally advanced disease had significantly higher incidences of NLR and DRR as compared to organ-confined disease. Patients with DRR> 1. 21 were at a greater risk of locally advanced disease in univariate LRMs. Similarly, in patients with NLR > 3. 47, there was an elevated risk of locally advanced disease. A DRR> 1. 21 in multivariable LRMs was an independent predictor of locally advanced disease. The AUC of the multivariate LRM was 0. 707, determining the possibility of locally advanced disease was 0. 07.

Source link: https://doi.org/10.1177/03915603211035191


The effect of COVID-19 on hepatic enzymes AST/ALT: A review

The increased synthesis of hepatic enzymes, mainly AST and ALT, as well as signs of inflammation, were discovered in ambiguous clinical studies, but the true source of inflammatory pathogenesis is still unclear. In coronavirus-positive patients, we reviewed the existing scientific evidence on COVID-19 and its effects on AST/ALT levels.

Source link: https://doi.org/10.53022/oarjbp.2022.5.2.0053


Incidence of hepatitis E virus among elevated liver enzyme (ALT, AST) Sudanese patients, Khartoum, Sudan

Abstract Background Hepatitis E Virus infection is a recently recognized significant threat to global public health, and Africa is thought to be one of the world's most contaminated regions.

Source link: https://doi.org/10.21203/rs.3.rs-1822696/v1


Changing Effects of Minimally Invasive Surgical Intervention on ALT, AST, and UA in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

This research aims to investigate the effects of obstructive sleep apnea syndrome on patients' liver and kidney function indices and monitor the changes in these indexes after minimally invasive surgery. Patients with OSAHS who were diagnosed via polysomnography and under minimally invasive surgery in the sleep disorders diagnosis and treatment center of the West China Fourth Hospital of Sichuan University from January 2017 to January 2019 were selected test subjects and placed in the OSAHS group. In patients with OSAHS who underwent minimally invasive surgery, these two groups were used to compare the differences in serum liver and kidney function and kidney function as well as evaluating the changes in sleep monitoring and kidney function indexes. There are some abnormalities in liver- and kidney-function-related indexes in patients with OSAHS, and minimally invasive surgery may be able to improve liver and kidney function in these patients.

Source link: https://doi.org/10.1155/2022/3622896


Population Pharmacokinetic Model of AST-001, L-Isomer of Serine, Combining Endogenous Production and Exogenous Administration in Healthy Subjects

AST-001, an L-isomer of serine, has anti-inflammatory properties on neurological disorders, has preventive effects on neurological disorders. To further develop a fixed-dose regimen in pediatrics, this study aimed to establish a population pharmacokinetic model of AST-001 in healthy Koreans. After a single dose of 10, 20, and 30 g of AST-001, the model was constructed using 648 plasma concentrations from 24 healthy volunteers, as well as baseline endogenous levels during 24 h and concentrations. The PK characteristics of AST-001 after oral administration were well defined by a two-compartment model with zero-order absorption and linear elimination. Both endogenous production and exogenous administration of AST-001 in healthy patients were well illustrated in the new population PK scheme. For the forthcoming phase 2 trial, we developed an optimal fixed-dose regimen with five weight ranges in pediatrics using the allometric scaling method.

Source link: https://doi.org/10.3389/fphar.2022.891227


Abstract CT044: AST-008, a TLR9 agonist spherical nucleic acid, activated NK cells, T cells, and cytokines in healthy subjects in a Phase I clinical trial

Abstract Background Excipure is a publication that discusses the development of spherical nucleic acid constructs, which are three-dimensional oligonucleotides in which the nucleic acids are densely packed and radially oriented around a nanoparticle. SNAs have characteristics that are distinguishable from those that are not, such as increased cellular uptake as compared to linear nucleic acids, and are, most notable, enhanced cellular uptake. AST-008 is a SNA version of a toll-like receptor 9 agonist oligonucleotide that is intended to stimulate anti-tumor immune responses in cancer patients. In several preclinical tumor models, AST-008 has potent antitumor activity as a monotherapy and synergizes with anti-PD-1 antibody therapy. In four cohorts, four dose levels of AST-008 were determined. According to baseline at the highest dose tested, AST-008 elicited 9. 5 fold and 3. 5 fold increases in the fraction of activated T cells and natural killer cells, respectively. These results indicate that the cytokines and immune cell activation by AST-008 will initiate and propagate the cancer immune cycle in the presence or absence of checkpoint inhibitors. The concentration of AST-008 in plasma peaked 2 hours after dosing and was dose proportional, according to pharmacokinetic analysis. A Phase 1b/2 study of AST-008 in combination with pesolizumab in cancer patients is ongoing. In a Phase I clinical trial [abstract], AST-008, a TLR9 agonist spherical nucleic acid, stimulated NK cells, T cells, and cytokines in healthy participants [abstract]. AACR Cancer Res 2019;79:Abstract nr CT044;; Proceedings of the American Association for Cancer Research Annual Meeting, 2019, Atlanta, GA.

Source link: https://doi.org/10.1158/1538-7445.am2019-ct044


Incidence of hepatitis E virus among elevated liver enzyme (ALT, AST) Sudanese patients, Khartoum, Sudan

Abstract Background Hepatitis E Virus infection is a recently recognized significant threat to global public health, and Africa is expected to be one of the world's most affected regions.

Source link: https://doi.org/10.21203/rs.3.rs-1739559/v1


Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

Abstract : The aim of this research is to investigate the relationship between the aspartate amino transferase/alanine aminotransferase ratio and all-cause mortality in stable coronary artery disease patients treated by percutaneous coronary intervention. ACM was present in 6 patients in the low group and 12 patients in the high group, among other things, with significant differences between the two groups. An elevated AST/ALT ratio in stable ACD patients was correlated with increased ACM in the Kaplan-u2013Meier study. Therefore, an elevated AST/ALT ratio in stable ACD patients is a risk factor for ACM.

Source link: https://doi.org/10.1038/s41598-022-13355-2

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions