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Substantial evidence indicates that liver function plays a vital role in brain health. A key regulator of brain function is a brain-derived neurotrophic factor. Therefore, we hypothesized that blood BDNF levels are correlated with liver function and fibrosis. We discovered that serum BDNF had a significant positive correlation with ALT and glutamyltranspeptidase production, negative correlation with the FIB-4 index, and a decline in inverse correlation with the AST/ALT ratio after age adjustment. These findings reveal correlations between serum BDNF and liver enzymes and hepatic fibrosis-related indices, which may underlie liver-brain interactions.
Source link: https://doi.org/10.1371/journal.pone.0273056
Alcohol withdrawal syndrome is a rare complication of chronic alcohol use that can lead to serious health issues. Our aim was to investigate the results of a short-scale AST in patients from public general hospitals. Patients attending the Emergency Department with AWS were enrolled in a cross-sectional study. All Sixty-eight males with a mean age of 41. 2 years old, high school education, and heavy alcohol intake were included. Mean scores for CIWA-Ar, GMWAS, and AST were 17. 4 1. 2, 3. 9 2. 6, respectively, without significant differences, with a wide range of values. According to CIWA-Ar, the AST scale's diagnostic results were similar to the GMAWS scale, demonstrating an sensitivity of 84%, specificity of 83. 3%, and Area Under the Curve of 0. 837 to distinguish severe AWS. The AST scale's ability to evaluate AWS is comparable to the commonly used CIWA-Ar and GMAWS scales.
Source link: https://doi.org/10.3390/ijerph19159208
Primary liver cancer is a common and lethal malignancy worldwide. The onset of liver cancer is insidious and often complicated with basic liver disease. AST-3424 is a prodrug of a potent nitrogen mustard that affects the tumor by its specific and selective mode of activation and results in the drug's concentration in the tumor, which also increases the risk of antitumor activity with reduced side effects. The aim of this study was to determine the in-vitro antitumor formation and mechanism of AST-3424 monotherapy and combination therapy with oxaliplatin or 5-fluorouracil.
Source link: https://doi.org/10.3389/fonc.2022.885139
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