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Aspartic Acid - DOAJ

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Last Updated: 10 July 2022

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Impact of Magnetite Nanoparticles Coated with Aspartic Acid on the Growth, Antioxidant Enzymes Activity and Chlorophyll Content of Maize

In exposed plant tissues, this research investigates the effects of the oxidative stress caused by magnetite nanoparticles coated with aspartic acid of 9. 17 nm mean diameter size on maize seedlings. Plant exposure to magnetite nanoparticles may cause oxidative stress, which causes the plant defense/antioxidant reactions to function.

Source link: https://doi.org/10.3390/antiox11061193


Detection of L-Aspartic Acid with Ag-Doped ZnO Nanosheets Using Differential Pulse Voltammetry

Here, a specialized voltametric electrochemical sensor probe was developed to accurately track the presence of L-aspartic acid in phosphate-buffered media using a glassy carbon electrode coated with a layer of wet-chemically prepared Ag 2 O-doped ZnO nanosheets. The differential pulse voltammetry was used for the trace detection of L-aspartic acid, and showed a wide detection range of 15. 0 – 105. 0 u00b5M, a limit of detection, as well as good sensitivity. In addition, the new aspartic acid was subjected to analysis to see aspartic acid in real biological samples.

Source link: https://doi.org/10.3390/bios12060379


The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats

In addition, we investigated the role of D-aspartate in the formation of LH and testosterone in rats' pituitary and testes, as well as the molecular mechanisms by which this amino acid causes its action. The effects of D-aspartate's synthesis of LH and testosterone were determined on isolated rat pituitary and Leydig cells. Tissues were incubated with D-aspartate, and then the concentration of LH and cGMP in the pituitary, as well as testosterone and cAMP in Leydig cells was determined. In the rat pituitary, sodium D-aspartate increases the release and synthesis of LH through the participation of cGMP as a second messenger, while in rat testis Leydig cells, it increases testosterone production and release as second messenger. The D-Asp is synthesized in the pituitary and in testes by a D-aspartate racemase, which converts L-Asp into D-Asp.

Source link: https://doi.org/10.1186/1477-7827-7-120


Aspartic Acid- and Glycine-Functionalized Mesoporous Silica as an Effective Adsorbent to Remove Methylene Blue from Contaminated Water

In this work, aspartic acid- and glycine-functionalized mesoporous silica nanoparticles were successfully manufactured and used as adsorbents for removal of methylene blue from contaminated water. The fabricated nanomaterials' mesoporous structure was confirmed by nitrogen adsorption/desorption of a limited surface area of ca. The average size of the nanoadsorbents was estimated to be ca. Asp-MSNs and Gly-MSNs' equilibrium adsorption capacity was discovered to be 55 mg/u22121 and 43 mg/u22121, respectively, under ideal conditions. The Langmuir model and pseudo-second-order equation had a good correlation with the isotherm and adsorption kinetic data for MB, respectively.

Source link: https://doi.org/10.1155/2022/5375815


Specific Adsorption of Aspartic Acid on Iron (III) and Nickel (II) Oxides

In the cases of aspartic acid in comparison with HCl, the presence of specific adsorption of aspartic acid anion and cation forms on Fe2O3 and NiO oxide surfaces, respectively. By spectrophotometer, the complexation process of Fe ions with aspartic acid in the bulk solution and on the oxide surface was investigated.

Source link: https://doi.org/10.18321/ectj126


Ultrasound and magnetic resonance imaging of cyclic arginine glycine aspartic acid-gadopentetic acid-polylactic acid in human breast cancer by targeting αvβ3 in xenograft-bearing nude mice

Breast cancer prevention by early detection is shown to have the ability to reduce breast cancer deaths. This research was designed to develop a targeted contrast agent for magnetic Resonance Imaging / ultrasound dual-modality molecular radiography for breast cancer. The cRGD-Gd-PTPA-PLGA's safety was demonstrated in vitro and in vivo, and their connection to breast cancer cells was shown. Moreover, MRI/ultrasound dual-modality radiography in vitro revealed that as the number of contrast agent increased, echo enhancement and signal intensity of MRI imaging had also increased. In the mouse tumor, the mouse models of human breast cancer also showed significant target enhancements of cRGD-Gd-DTPA-PLGA magnetic nanoparticles. In breast cancer, we also investigated the targeting mechanism of cRGD-Gd-DTPA-PLGA in breast cancer. The results revealed that u03b1vu03b23 was highly expressed in breast cancer tissues, and cRGD-Gd-PLGA was used for MRI/ultrasound dual-modality molecular radiography, with the target u03b1v-u03b23. Breast cancer survivorship is monitored by the state of neovascularization, according to the cRGD-Gd-DTPA-PLGA system.

Source link: https://doi.org/10.1080/21655979.2022.2045832


Photo Irradiation-Induced Core Crosslinked Poly(ethylene glycol)-block-poly(aspartic acid) Micelles: Optimization of Block Copolymer Synthesis and Characterization of Core Crosslinked Micelles

The core crosslinked micelles were not dissociation in the optimized environment, while non-CCL micelles dissociated, indicating dissociation. Measurement of micellar-formation stability of CCL micelles and that of non-CCL micelles showed a difference between the micellar-formation stability of CCL micelles and that of the non-CCL micelles. The CCL micelles were more stable than non-CCL micelles, according to CPC experiments, making them more stable than non-CCL micelles. In conclusion, the prepared CCL micelles had the same diameter, the same formula, and the same inner-core characteristics for drug encapsulation as the non-CCL micelles. In addition, the CCL micelles developed non-dissociable micelle formation, while the non-CCL micelles dissociated into single block copolymers.

Source link: https://doi.org/10.3390/polym9120710


Opposing effects of D-aspartic acid and nitric oxide on tuning of testosterone production in mallard testis during the reproductive cycle

For the first time in birds, we have investigated the putative effects of D-Asp and NO on testicular testosterone production in relation to two phases of the adult captive wild-strain mallard drake's reproductive cycle. During the key phases of the bird's reproductive cycle, the presence and the localization of D-Asp and NO in the testis as well as the trends of D-Asp, NO, and testosterone levels were investigated. In addition, in vitro studies, the immediate effects of exogenously administered D-Asp and NO on testosterone steroidogenesis was shown by experiments. Methods We investigated the presence and distribution of D-Asp and NO in the testes of RP and NRP drakes using immunohistochemical techniques. D-Asp was almost exclusively present during the RP, although NO was present only during the NRP. The high testosterone testicular content included during RP was related to a high D-Asp level and a low NO content in the gonad, which was consistent. Therefore, we carried out in vitro experiments using testis sections deriving from both the RP and NRP to determine the exogenous effects of the two amino acids on testosterone synthesis. Conclusion The adult captive wild-strain mallard drake's D-Asp and NO results provide new insight into the role of D-Asp and NO in testicular testosterone production. These two molecules' localization in Leydig cells during different phases of the reproductive cycle reveals that they may play a role in regulating local testosterone production.

Source link: https://doi.org/10.1186/1477-7827-6-28

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions