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Aspartic Acid - Europe PMC

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Last Updated: 10 November 2022

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Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment.

One of the most common ischemic heart diseases is acute myocardial infarction. However, a key factor in treatment failure is a lack of adequate drug concentration. A novel nano-system was designed to investigate the anti-AMI capabilities of calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-glycyl-glycyl-aspartic acid peptide co-modified nano-system. We developed the CAL and TAN combined lipid-polymer hybrid nano-system, and RGD was upgraded to the device in order to achieve RGD-CAL/TAN NS. In AMI rats' model, the AMI therapy capabilities of the devices was investigated. According to MTP/RGD-CAL/TAN NS, the area under the curve and blood circulation half-life was 178. 86;u00b1 6. 62 h, respectively. : U03bcg/u00b1 6. 62 mL and 0. 47 h MTP/RGD-CAL/TAN NS had the most significant infarct size reduction effect of 22. 9%, with a median reduction of 21. 9 percent. MTP/RGD-CAL/TAN NS had the highest heart formation and largest infarct size reduction effect, which could be used as a promising treatment of cardiovascular disease.

Source link: https://europepmc.org/article/MED/36047255


Poly(aspartic acid)-based self-healing hydrogel with precise antibacterial ability for rapid infected-wound repairing.

In treating bacterial wound infection, wound dressings with antibacterial activity and simultaneous pro-healing functions are always important. This hydrogel not only increases the biocompatibility of quaternary poly, but also increases antibacterial activity by pH-triggering dissociation under low pH bacterial microenvironment. Under near-infrared light, a strong synergistic antibacterial activity was evidently higher than a single antibacterial regiment, according to a qualitative in vitro report. In vivo results showed an optimal healing rate after 7 days in wounds treated with the hydrogel. Hence, the novel polyhydrgel may be a promising candidate for precise therapy of bacteria-infected wounds.

Source link: https://europepmc.org/article/MED/36347184


Aspartic acid and epidermal growth factor modified decellularized rabbit conjunctiva for conjunctival reconstruction.

Decellularized matrix has been regarded as an excellent conjunctival substitute for conjunctival reconstruction. We present evidence from the current research describing the use of a decellularized rabbit conjunctiva for conjunctival reconstruction in the rabbit surgical trauma model. DRC-Asp-EGF was used as a spacer arm to crosslink epidermal growth factor on the DRC in order to raise the DRC's success, resulting in DRC DRC's DRC growth factor. Cultured on the DRC-Asp-EGF, with higher survival rates and a greater ability to differentiate into conjunctival goblet cells than those on the DRC. DRC-Asp-EGF group, amniotic membrane group, and ungrafted groups were all set to evaluate transplantation results in the rabbit surgical trauma model for 28 days. DRC-Asp-EGF is a cost-effective and safe transplant for conjunctival repair and ocular surface rejuvenation, according to these results.

Source link: https://europepmc.org/article/MED/36343391


Exogenous aspartic acid alleviates salt stress-induced decline in growth by enhancing antioxidants and compatible solutes while reducing reactive oxygen species in wheat.

According to published research, aspartic acid helps plant tolerance against salinity stress. Therefore, exogenous application of aspartic acid in raising wheat plants' tolerance to salt stress was conducted in a completely randomized setting in this work. Wheat plants were sown with different degrees of salinity and treated with three levels of exogenous application of aspartic acid foliar spray. However, Asp's application improved photographsynthetic pigments and endogenous indole acetic acid, therefore improving plant leaf area, resulting in increased biomass dry weight either under salt-stressed or non-stressed plants. The quadratic regression model explained 100% of the shoot dry weight yield variation, according to the results. This report found that the exogenous use of aspartic acid reduced the adverse effects of salt stress damage on wheat plants and provided economic benefits.

Source link: https://europepmc.org/article/MED/36325561

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions