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Aspartic Acid - Crossref

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Last Updated: 10 November 2022

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Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57

Toluene diisocyanate, the most common cause of occupational asthma in western countries, is Toluene diisocyanate. We investigated the prevalence of human leucocyte antigen class II genetic markers in three groups of participants: 1 subjects with TDI-induced asthma n = 30; 2 exposed subjects with no history of TDI-induced asthma n = 12; and 3 healthy controls not exposed to TDI-induced asthma n = 126. DQA and DQB gene expressions were obtained from the three organizations, and the polymorphic second exon of DQA and DQB genes was amplified by the polymerase chain reaction PCR technique. The evaluation of HLA class II gene products in TDI-induced asthma patients revealed a positive correlation with HLA-DQB1 * 0503 and a negative association with HLA-DQB1 * 0501 alleles, which differed at residue 57 for a single amino acid, i. e.

Source link: https://doi.org/10.1183/09031936.96.09020207


An inorganic–organic hybrid supramolecular framework based on the γ-[Mo 8 O 26 ] 4− cluster and cobalt complex of aspartic acid: X-ray structure and DFT study

Aspartic acid acts as a bridge between the two Co atoms and the Mo centers in this compound, with the u2013CH 2 COOH side chain closely tied to the Mo center in u3312 [Mo 8 O 26 ] 4u2212 and the u03b1-carboxylate chain tied to the Co center chain. The binding of transition-metal complexes to POMs, according to a granular ligand of Mo and Co atoms, requires coordination of the metal to a terminal O atom of the POM, ensuring that 1, with a bridging ligand between Mo and Co atoms, belongs to a special class of hybrid materials. Although the starting materials are both chiral and one might imagine them to create a chiral hybrid, the decomposition of the chiral Evans's POM and its conversion to the centrosymmetric baugable POM, as well as the presence of two aspartate ligands centrosymmetrically placed on either side of the POM lead to the formation of an achiral hybrid.

Source link: https://doi.org/10.1107/s2053229619004029


A comparative study of two polymorphs of L -aspartic acid hydrochloride

Two polymorphs of L-aspartic acid hydrochloride, C 4 H 8 N =u2212, were obtained from the same aqueous solution. The cations and anions are linked to one another by N. . Cl and OJu2014H. . Cl interactions and result in alternating cation layer-like structures. In addition, the orthorhombic polymorph's molecular packing adds to the orthorhombic polymorph's more complex interactions, which may be a contributing factor for more effective charge transfer within the crystal.

Source link: https://doi.org/10.1107/s2053229614013163


Both Amide-Bearing α- and β-Amino Acids from Natural Aspartic Acid Are Efficient Organocatalysts for Enantioselective Aldol Reactions

Interestingly, aspartic acid is not only u03b1-amino acid, but also a u03b2-amino acid. Interestingly, the two species of amino acid obtained similar high catalytic efficiencies in the asymmetric aldol transformation under different ideal conditions. In this asymmetric transition, the preferred u03b2-amino acid had even higher enantioselectivity in some cases, even better than the desired u03b1-amino acid, but u03b1-amino acids were found to be highly effective organocatalysts.

Source link: https://doi.org/10.1055/a-1953-1656


High Frequency of Aspartic Acid at Position 57 of HLA-DQ β-Chain in Japanese IDDM Patients and Nondiabetic Subjects

Alleles carrying an aspartic acid were present on position 57 of the DQ 57-Block Chain, 35 were Asp 57/non-Asp 57 heterozygous, with three others having non-Asp 57 alleles exclusively, with two others having non-Asp 57 alleles only. Both IDDM and control subjects have high incidence of Asp 57 alleles, contrasting with whites' results. Also, the Asp 57's argument that the presence of an aspartic acid at position 57 of DQ's U03b2-chain provides protection against developing IDDM is not tenable for Japanese IDDM patients.

Source link: https://doi.org/10.2337/diab.39.2.266


Exogenous aspartic acid alleviates salt stress-induced decline in growth by enhancing antioxidants and compatible solutes while reducing reactive oxygen species in wheat

Aspartic acid was identified in plant resistance to salinity stress in published studies, which also showed that aspartic acid could be responsible for increased plant tolerance against salinity stress. In the present work, empirical pot trials in a completely random setting were conducted to investigate the possibility of exogenous application of aspartic acid in improving wheat plants''s resistance to salt stress. According to the results of the analysis, salinity stress reduced growth indicators such as rifle length, leaf area, and shooting biomass, as well as photosynthesis pigments and endogenous indole acetic acid. However, Asp applications enhanced photosynthetic pigments and endogenous indole acetic acid, increasing plant leaf area and raising biomass dry weight whether under salt-stressed or non-stressed plants. This report found that the exogenous application of aspartic acid mitigated the adverse effects of salt stress on wheat plants and provided economic benefits.

Source link: https://doi.org/10.3389/fpls.2022.987641


Biogenic Synthesis of Gold Nanoparticles from Aspartic Acid - A Preliminary Study

A nanoparticle is ultra-fine particle with a single dimension between 1-100 nanometers. Gold nanoparticles are of utmost importance in research. Aspartic acid is an alpha amino acid that has one amino group and one carboxylic group. Aspartic acid was used to synthesize gold nanoparticles in the current study. With stirring at 45°u00b0C, AuCL3 solution was gradually added to 250 aspartic acid with gradual stirring at 45°u00b0C. 24 hours revealed an increased rate and a Surface Plasmon Resonance band at 575 nm, with an increased ferocity and a Surface Plasmon Resonance band at 575 nm. The gold nanoparticles obtained by Transmission electron microscopy were found to be spherical in form and diameter 20 nm. AuNPs were produced from the aspartic acid in a simple and cost-effective manner. In approx. , nano particles were first introduced in approx. Peak absorbance at 24 hours at 575nm was peak absorbance at 9 hours in 9 hours at 575nm, a peak absorbance of peak absorbance at 24 hours.

Source link: https://doi.org/10.9734/jpri/2020/v32i1830685


Bone-Targeting Nanoparticles of a Dendritic (Aspartic acid)3-Functionalized PEG-PLGA Biopolymer Encapsulating Simvastatin for the Treatment of Osteoporosis in Rat Models

In a local bone loss of hindlimb suspension model, bone-targeting SIM/APP NPs demonstrated greater bone formation in comparison to non-bone-targeting SIM/PP NPs, but no bone regeneration was found in a postmenopausal model of systemic bone loss. The APP NPs were shown to effectively target high mineral levels in bone tissue and were supposed to minimize side effects in other organs that were affected by SIM. However, in vivo OP model validation, the same lower dose could not be used to treat various types of OP.

Source link: https://doi.org/10.3390/ijms231810530


Effect of Ocular Hypertension on D- β -Aspartic Acid-Containing Proteins in the Retinas of Rats

As an experimental model, adult Wistar rats with ocular hypertension were used as an experimental model. SDS-PAGE and western blot used an anti-D-u03b2-containing proteins, which were isolated by SDS-PAGE and western blot with an anti-D-u03b2 -aspartic acid antibody and identified by liquid chromatography-mass spectrometry analysis. Aspartic acid was present in a protein band at about 44. 5 kDa in rats with ocular hypertension in the retinas of rats with ocular hypertension in rats with ocular hypertension in a protein band at a rate much higher rate in ocular hypertension in the retinas of ocular hypertension in ocular hypertension in normotensive rats in the retinas of normotensive rats in a protein band at kDa The expression of proteins containing D-aspartic acid, including ATP synthase subunits, and up-regulation of ATP in rats' retinas was influenced by ocular hypertension.

Source link: https://doi.org/10.1155/2019/2431481

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions