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Using a transcription- and replication-competent VLP system, we revealed that HERC5 hinders EBOV virus-like fragment replication by diminishing EBOV mRNAs. Additionally, we revealed that EBOV glycoprotein but not Marburg virus general practitioner antagonized HERC5 early throughout infection. Our information identify a novel 'protagonist-antagonistic' relationship in between HERC5 and general practitioner in the beginning of EBOV infection that could be manipulated for the advancement of novel antiviral therapeutics.
Source link: https://europepmc.org/article/MED/34572049
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