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Antagonist - U.S. Department of Veterans Affairs

Summarized by Plex Scholar
Last Updated: 10 April 2022

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Antagonist of growth hormone-releasing hormone MIA-690 attenuates the progression and inhibits growth of colorectal cancer in mice.

Colorectal cancer is an aggressive tumor in which new treatment techniques have had no effect on cure rates and long-term survival. In several experimental tumors, growth hormone-releasing hormone antagonists have been shown to have anticancerogenic effects, but their role in CRC is uncertain. We found that chronic treatment of experimentally induced colitis-associated cancer in mice with a GHRH antagonist of MIAMI class MIA-690 improved survival and gradually halted tumor formation, paralleled by reduced inflammation in colon tissue. In addition, MIA-690 reduced the protein expression of c-Myc, P-AKT, and Bcl-2, as well as upregulated p53 protein expression.

Source link: https://doi.org/10.1016/j.biopha.2021.112554

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions