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ANTAGONIST - DOAJ

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Last Updated: 10 August 2022

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Characterization of Patients with Chronic Obstructive Pulmonary Disease Initiating Single-Inhaler Long-Acting Muscarinic Antagonist/Long-Acting β2-Agonist Dual Therapy in a Primary Care Setting in England

Methods and Methods: A retrospective review of patients with COPD who initiated single-inhaler long-acting muscarinic antagonist/long-acting dual therapy in primary care in England using linked information from Clinical Practice Research Datalink Aurum and Hospital Episode Statistics datasets. Patients with COPD who have a single-inhaler LAMA/LABA prescription between June 2015 and December 2018 were included in the study. At 12 and 3 months pre-index across indexed therapies, only respiratory therapy was prescribed at these time points; 42. 5 percent of patients were told no respiratory therapy at any time points. Original key words: COPD, initial maintenance therapy, primary care setting, patient characteristics, single-inhaler LAMA/LABA dual therapy, and treatment trends: Two years before LAMA/LABA's establishment, half of non-triple users were not receiving respiratory therapy, primary care setting, patient characteristics, and general care in England: Key words: first respiratory therapy, respiratory training, respiratory care setting, patient characteristics, one-year absence, and treatment trends.

Source link: https://doaj.org/article/15277e633377435dab660ea8e3830885


Evaluation of pregnancy outcomes using medroxyprogesterone acetate versus gonadotropin-releasing hormone antagonist in ovarian stimulation: A retrospective cohort study

In ovarian stimulation protocols, limited studies have compared pregnancy results with medroxyprogesterone acetate vs. gonadotropin-releasing hormone antagonist. This research seeks to investigate pregnancy outcomes with the help of MPA rather than a GnRH antagonist for ovarian stimulation in donor-recipient cycles. The study included 250 donors undergoing ovarian stimulation with two different protocols: group 1 received GnRH antagonist from the 5th or 6th day of menses, while group 2 received MPA from the second day of menses. The results revealed that live birth was comparable in both recipient groups. However, the implantation rate with twin sacs was significantly lower in group 2 compared to group 2. In both donor groups, the regression results for good-quality blastocyst proportion was similar. In group 2's mean stimulation cost was less than in group 1 but not less than in group 1. MPA had similar live birth and embryological outcomes in both groups.

Source link: https://doi.org/10.18502/ijrm.v20i6.11445


Modulation of ankle antagonist co-activation during the transition from upright standing to gait and to sit in post-stroke subjects

Methods and methods This paper is a cross-sectional study aims to investigate ankle antagonist co-activation in various occupational tasks in post-stroke patients. During functional tasks and p-values obtained from inter-limb and inter-task comparisons, antagonist co-activation during developmental tasks and interquartile ranges of inter-task and inter-task comparisons was found by a median and interquartile range of antagonist co-activation. According to Table: see text; table: see text; discussed text; and conclusions When an appropriate antigravity function and coordination of the tibia forward rotation are required, respectively, the IPSI and CONTRA limbs displayed increased antagonist co-activation. The comparison of these results with those obtained by healthy people [3,4] indicates a bilateral postural control deficit in post-stroke patients due to tonus modulation deficiencies that should be addressed in neurorehabilitation.

Source link: https://doi.org/10.1080/07853890.2021.1896620


Neutrophil extracellular traps are involved in enhanced contact hypersensitivity response in IL-36 receptor antagonist-deficient mice

Mice from Il3612/u2212 mice have an elevated contact hypersensitivity response when stimulated neutrophil recruitment, as shown by previous studies. Also, the NET formation blockade improved the CHS response, which in turn reduced inflammation cell infiltration and NET formation, which consequently decreased inflammatory cell infiltration and NET formation. These results show that IL-36Ra deficiency contributes to the CHS response caused by increased inflammatory cell recruitment, NET generation, and cytokine and chemokine manufacturing, as well as the NET formation blockade, which improves the CHS response. Hence, NET connectivity may play a vital role in the CHS response.

Source link: https://doi.org/10.1038/s41598-022-16449-z


Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist-Implications for male fertility.

The effects of Stinging nettle root and leaf extracts were investigated on prostatic smooth muscle contractility. Root extract did not have a direct effect on electrical field stimulation, which caused nerve-mediated contractions of isolated rat prostates. In mouse mating experiments, stinging nettle leaf extract reduced male fertility by 53% compared to vehicle-treated male mice. In stinging nettle leaf extract treated mice, Bladder and testes weighed less. It is found that stinging nettle leaf extract reduces the contractility of genitourinary smooth muscle by acting as an enemy at postjunctional P2X1-purinoceptors.

Source link: https://doi.org/10.1371/journal.pone.0271735


The Effects of Intra-Ductal Mammary Administration of Orexin-A Antagonist (SB-334867) on the PPARγ and SREBP1c Gene Expression and Serum Adiponectin Levels in Lactating Rats

The aim of this investigation was to determine the effects of mammary administration of the orexin A receptor antagonist on the expression of PPARu03b3 and SREBP1c genes, as well as serum adiponectin levels in the lactating rats. Orexin B receptor antagonist was intraductal into the mammary glands of lactating female rats in three doses of 1, 2 and 4 bcg/kg BW in a solvent volume of 50 bcl. BW SB's rate of reduction at a dose of 4 bb5g/kg BW SB was higher than those of 1 and 2 g/kg BW SB, 334867. These results revealed that intra-mammary administration of a 4 g/kg orexin-A antagonist in lactating rats reduced the gene expression of two transcription factors involved in milk fat formation, as well as a decrease in serum adiponectin levels.

Source link: https://doi.org/10.34172/ijbsm.2022.04


Role of sphingosine 1-phosphate (S1P) and effects of fingolimod, an S1P receptor 1 functional antagonist in lymphocyte circulation and autoimmune diseases

Sphingosine kinases and binds to five well-known G protein-coupled S1P receptors, leading to sphingosine kinases and binds to five well-known Sphingosine 1-phosphate, a multi-functional phospholipid mediator. S1P receptor 1 is widely believed to play a significant role in lymphocyte migration from these organs and thymus, since lymphocyte egress from these organs to periphery is at such low levels in mice lacking lymphocytic S1P1. Fingolimod hydrochloride, a first-in-class, orally active S1P1 functional antagonist, which was discovered by chemical modification of a natural product, myriocin. Since the FTY720 has a structure closely related to sphingosine, the phosphorylated FTY720 is converted by sphingosine kinases and binds 4 types of S1P receptors, it is closely related to sphingosine. Oral FTY720 shows a higher rate of performance in remitted MS patients, as compared to intramuscular interferons U03b2-1a.

Source link: https://doi.org/10.3934/molsci.2014.4.162


A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure

Abstract Background : Valproic acid is a commonly used antiepileptic drug, but it is also linked to a low verbal intelligence quotient, attention deficit hyperactivity disorder, and autism spectrum disorder in children when it is administered during pregnancy. VPA exposure during pregnancy has been shown to influence neurogenesis and neuronal migration and differentiation. In addition, growing evidence has shown that VPA therapy activates microglia and brain immune cells. On the E11. 5", pregnant female mice received sodium valproate, according to Pregnant Female Mice. Prenatal exposure of mice to VPA-induced microglial cell dysfunction in the CA1 region of the hippocampus during early postnatal and post-developmental impairments in learning recall and social interaction in repetitive habits. Prenatal VPA exposure increases neural circuit dysfunction and post-developmental developmental disorders. maraviroc, a CCR5 antagonist, has significantly reduced neural circuit dysfunction and post-developmental behavioral disorders. When given early, CCR5-targeting drugs such as maraviroc could help with behavioral disorders.

Source link: https://doi.org/10.1186/s12974-022-02559-y


The preventive effect of low-dose aspirin in a PPAR-γ antagonist treated mouse model of preeclampsia

Abstract Background Preeclampsia is one of the most common causes of maternal and perinatal mortality and morbidity. According to various recommendations, low-dose aspirin is the most commonly used drug to prevent PE, but the recommended dose of LDA varies according to individual guidelines. Peroxisome proliferator-activated receptor -u03b3 is involved in the birth of the placenta during pregnancy and is present in women with elevated PE. PAR-u03b3: We wanted to see if aspirin involvement in preeclampsia was related to PPAR-u03b3. At 8. 5°u201312. 5 days of pregnancy, we gave pregnant mice with a PPAR-u03b3-specific antagonist 2 mg/d. LDA's contribution to the rise in blood pressure in mice caused by T00907 and reduced urinary protein levels and the urinary protein/creatinine ratios has greatly reduced. 20 mg LDA had a much better effect than that of ten mg. LDA's protective effect against PE is dose-dependent.

Source link: https://doi.org/10.1186/s12884-022-04901-x


The CCR5 antagonist maraviroc exerts limited neuroprotection without improving neurofunctional outcome in experimental pneumococcal meningitis

Abstract One-third of pneumococcal meningitis survivors suffer from neurological disorders such as learning difficulties and hearing loss as a result of elevated neuroinflammation. CCR5 antagonistu2014 Maraviroc u2014 was shown to reduce leukocyte recruitment and attenuate neuroinflammation in several inflammatory disorders. MVC decreased nitric oxide production in astroglial cells on pneumococcal stimulation, according to here. Infant Wistar rats were infected with 1 104 CFU/ml S. pneumonia and randomized for ceftriaxone plus MVC or ceftriaxone monotherapy, according to In vivo. MVC therapy improved hippocampal cell apoptosis during PM but did not have an effect on CSF neuroinflammation or the neurochemical outcome.

Source link: https://doi.org/10.1038/s41598-022-17282-0

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions