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ANCESTRAL - BioRxiv

Summarized by Plex Scholar
Last Updated: 10 June 2022

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Recoverability of Ancestral Recombination Graph Topologies

"We investigate the likelihood of reconstructing the true topology of ancestral recombination graphs under the coalescent's coalescent with recombination and gene conversion. " We explore how sample size and mutation rate influence the inherent uncertainty in reconstructed ARGs, which helps to clarify the theoretical limitations of ARG reconstruction methods. We illustrate our findings by estimating evolution rates for many animals, including SARS-CoV-2; in particular, we find that for parameter values that are realistic for SARS-CoV-2, the likelihood of reconstructing genealogies that are closest to the truth is low. ".

Source link: https://doi.org/10.1101/2021.10.10.463724

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions