ALT - Springer Nature

Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study

"The aim of this study is to investigate the correlation between the aspartate amino transferase/alanine aminotransferase ratio and all-cause mortality in stable coronary artery disease patients treated by percutaneous coronary intervention. " ACM was present in 6 patients in the low group and 12 patients in the high group, among them, with significant differences between the two groups. An elevated AST/ALT ratio in stable ACD patients was correlated with an elevated ACM in the Kaplanu2013Meier study. Accordingly, an elevated AST/ALT ratio in stable ACD patients is an independent prognostic factor for ACM.

Source link: https://doi.org/10.1038/s41598-022-13355-2

A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation

"Nonalcoholic fatty liver disease is a common cause of chronic liver disease. " 90,408 cALT patients and 128,187 controls used a proxy NAFLD measure of chronic elevation of alanine aminotransferase levels in liver diseases without other liver diseases. External replication in histology-defined NAFLD cohorts or radiologic imaging cohorts replicated 17 single-nucleotide polymorphisms, of which 9 were new. A multiancestry genome-wide association research of chronic alanine aminotransferase elevation uncovers candidate risk loci for nonalcoholic fatty liver disease, with parallel in other cohorts defined by histology or imaging.

Source link: https://doi.org/10.1038/s41588-022-01078-z

Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor

"develop a chemoproteomic pipeline to find nascent unannotated alt-proteins and reveal that cell-cycle-regulated alt-protein MINAS-60 is a checkpoint inhibitor of pre-60S assembly. We developed a chemoproteomic pipeline to find nascent alt-proteins in human cells, owing to the belief that alt-proteins undergoing controlled synthesis could play significant cellular functions. We found 22 regularly translated alt-proteins or N-terminal extensions, one of which is specifically regulated by DNA damage stress, and one of which is also restricted by DNA damage stress. These findings demonstrate that chemoproteomics enables hypothesis generation for unidentified alt-proteins and implicates MINAS-60 as a potential checkpoint inhibitor of pre-60S assembly.

Source link: https://doi.org/10.1038/s41589-022-01003-9

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