Advanced searches left 3/3

ALT - Europe PMC

Summarized by Plex Scholar
Last Updated: 10 June 2022

* If you want to update the article please login/register

Elevated AST/ALT ratio is associated with all-cause mortality in patients with stable coronary artery disease: a secondary analysis based on a retrospective cohort study.

"The aim of this study is to investigate the relationship between the aspartate amino transferase/alanine aminotransferase ratio and all-cause mortality in stable coronary artery disease patients treated by percutaneous coronary intervention. " ACM was present in 6 patients in the low group and 12 patients in the high group, among them, with significant differences between the two groups indicating significant differences. In the Kaplan-Meier study, an elevated AST/ALT ratio was associated with increased ACM in stable ACD patients. An elevated AST/ALT ratio in stable ACD patients is therefore an independent prognostic factor for ACM.

Source link: https://europepmc.org/article/MED/35654995


A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

"Nonalcoholic fatty liver disease (LCHF) is a common cause of chronic liver disease. " 90,408 cALT cases and 128,187 controls used a proxy NAFLD definition of persistent elevation of alanine aminotransferase levels in those liver diseases. External replication in histology-defined NAFLD cohorts or radiologic imaging cohorts was replicated by 17 single-nucleotide polymorphisms, of which 9 were new. Our integrated approach, which includes cALT, histology, and imaging, provides new insights into genetic factors that lead to NAFLD.

Source link: https://europepmc.org/article/MED/35654975


Low AST/ALT ratio is a predictor of diabetes incidence in Japanese people: Population-based Panasonic cohort study 5.

"Aims" was the aim of this study to determine the risk of incident type 2 diabetes and investigate the relationship between liver enzymes and incident DM in participants with or without obesity. Using Cox regression results, the possibility of incident type 2 DM was investigated according to cut-off values of liver enzymes and group with BMI u226525 kg/m 2 calculated. According to the table, incident DM in subjects with ALT 226523 or AST/ALT 0. 99 and BMI 25 kg/m 2 were higher than those with incident DM 25 kg/m 2 or AST/ALT > 0. 875, respectively. Non-obese people with AST/ALT > 0. 875> had a higher risk of event type 2 DM than obese people with AST/ALT > 0. 875.

Source link: https://europepmc.org/article/MED/35654736


MEDB-68. Analysis of telomeres length and Alternative Lengthening of Telomeres (ALT) in molecular subgroups of infant medulloblastoma

"Abstract In a infant medulloblastoma cohort, we investigated the relationship between the molecular profile and telomere length, which was retrospectively determined. " The activation of telomere maintenance mechanisms was investigated to see if the senescence escape caused by telomere-elongation mechanisms could explain the aggressivity of some iMBs belonging to the same molecular subgroup's aggressivity. ALT was found to be activated in 10% of iMBs and was not specific to any molecular subgroup, implying that it may be a potential cause of aggressive behavior in a subset of iMBs. In the telomere length distribution among the iMB molecular subgroups, SHH iMBs had a greater incidence of High telomere length than NON-SHH/NON-WNT iMBs, which were more commonly associated with Medium telomeres length. CONCLUSIONS: ALT activation in infant MBs could be a new point for risk-stratification and personalized therapy. ".

Source link: https://europepmc.org/article/MED/PMC9164930

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions