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Last Updated: 10 November 2022

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A Prediction Model for Chemotherapy-Induced Thrombocytopenia Based on Real-World Data and a Close Relationship Between AST/ALT Ratio and Platelet Count in Patients with Solid Tumors

Methods and Methods: A total of 2043 patients treated by chemotherapy from Jun 1, 2017 to Dec. 20, 2021, were retrospectively enrolled in a CIT-predicting model based on the laboratory indices of cancer patients receiving chemotherapy. Patients with solid tumors were referred to a generalized additive mixed model to analyze the changes in aspartate aminotransferase's changes, from AST to alanine transaminase, and platelet count in patients with solid tumors. The risk of CIT was strongly associated with AST level, AST/ALT ratio, and total bilirubin, white blood cell, platelet, and hemoglobin levels, according to a multivariate analysis. PLT level was inversely related to AST/ALT ratio and AST level, but not with AST/ALT ratio and AST level, more significantly with AST/ALT ratios. The GAMM report found that PLT levels were closely linked with AST/ALT ratio and AST level, as well as the AST/ALT ratio and AST level, as well as the AST/ALT ratio and AST/AST ratio. Conclusion: The AST/ALT ratio was inversely associated with the CIT risk in cancer patients in a region under the receiver operating characteristic curve of 0. 793, with a sensitivity of 0. 543 and a specificity of 0. 930.

Source link: https://doaj.org/article/ececa345c08749d7b3e7ed541bb7988e


Dual Innervation in Anterolateral Thigh (ALT) Phalloplasty: Consider the Femoral Perforating Nerves

Sensation following anterolateral thigh phalloplasty is traditionally seen as inferior to sensation following radial forearm phalloplasty, owing to fewer nerve coaptations conducted. To determine nerve coaptations used in ALT phalloplasty, a PRISMA literature review was conducted. Eleven research examines ALT phalloplasty innervation, and 16 of them mention the use of only one nerve coaptation with the lateral femoral cutaneous nerve nerve. The first nerve nerves to be uncovered on the medial border of the ALT flap, which is the sartorius, are those of a perplexing branch of the femoral nerve. The femoral nerves can innervate a significant portion of the phallic shaft, where sensation is most desired with a flap style where the urethra is based laterally. With the lateral femoral cutaneous nerve, it is common to perform only one nerve coaptation in ALT phalloplasty.

Source link: https://doi.org/10.1097/GOX.0000000000004545


Inexpensive, Accurate, and Stable Method to Quantitate Blood Alanine Aminotransferase (ALT) Levels

Alanine aminotransferase levels are often found in serum and plasma samples, and they are a common way to determine hepatocellular injury in rodents, humans, and other animals. In addition, anticoagulation of blood samples using ethylenediaminetetraacetic acid or heparin shows similar ALT values assay, though no anticoagulation significantly raises ALT values. Mild hemolysis does not significantly raise ALT levels, but moderate to severe hemolysis does lead to elevated ALT values. In serum and plasma samples from rodents and humans with dyslipidemia, the assay delivers consistent results on a variety of related triglyceride concentrations that can be expected. It also does well in diluted samples with a decrease in ALT levels corresponding to the factor used to dilute the samples. The outlined ALT reagent is also very inexpensive, costing less than 1/80 of comparable commercial kits.

Source link: https://doi.org/10.3390/mps5050081


Association between ALT/AST and Muscle Mass in Patients with Type 2 Diabetes Mellitus

The alanine aminotransferase/aspartate aminotransferase ratio is believed to be related to metabolic disorders and insulin resistance. Low muscle mass is a high risk group for Type 2 diabetes mellitus. In patients with T2DM, this study was done to determine the relationship between ALT/AST and muscle mass. T2DM patients were enrolled in this cross-sectional study, which included 102 people. Using dual-energy X-ray absorptiometry, a Skeletal muscle index was discovered. In patients with T2DM, a logistic regression test was used to determine the relationship between ALT/AST and low muscle mass in patients with T2DM. Both genders had an elevated risk of low muscle mass. In the male group, SMI was negatively related to ALT/AST, age, glycosylated hemoglobin, and high-density lipoprotein cholesterol. SMI was positively linked to systolic blood pressure in the female group and was not negatively associated with ALT/AST and age. In T2DM patients with muscle mass, ALT/AST was negatively related to muscle mass.

Source link: https://doi.org/10.1155/2022/9480228


Viral Load and Alanine Amino Transferase (ALT) in Hepatitis B Positive Individuals at a Tertiary Level Care Hospital

In a tertiary care facility in Rawalpindi, the aim of the study is to see the Co-relation in between ALT and viral load of HBV positive people. Study was conducted during the first six months of 2019 from first January to June 30th at Holy Family Hospital. The following patients with HBV positive and age over 18 years were identified in a study that ran from January 2019 to June 2019 were included. Data was entered and analyzed by using the statistical package for social sciences version 21 for frequencies cross tabulations and co relation. Conclusion: ALT is not a true representative of viral load in hepatitis B. A low ALT can result in high viral load and high viral load, but a high ALT can be found with low viral load.

Source link: https://doaj.org/article/5cd8250ae6124d018f69c41380d87634


TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

Here, we find that the majority of these ALT tumors are ATRX wildu2010type and instead have an amplified 17p11. 2 chromosomal region containing TOP3A. We established the cellular significance of these findings by showing that TOP3A overexpression in ALT cancer cells countered ATRX-mediated ALT inhibition and that TOP3A knockdown disrupted the ATRXu2010wt cell phenotype in ATRXu2010wt cells, which demonstrated the functional significance of these findings. In addition, we find that TOP3A is also required for proper BLM localization and promotes ALT DNA synthesis in ALT cell lines.

Source link: https://doi.org/10.15252/emmm.202215859

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions